{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:23:30Z","timestamp":1789982610182,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1ZIANS002974"],"award-info":[{"award-number":["1ZIANS002974"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the safety and efficacy of a home\u2010based functional exercise program in spinal and bulbar muscular atrophy (<jats:styled-content style=\"fixed-case\">SBMA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were randomly assigned to participate in 12\u00a0weeks of either functional exercises (intervention) or a stretching program (control) at the National Institutes of Health in Bethesda, <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. A total of 54 subjects enrolled, and 50 completed the study with 24 in the functional exercise group and 26 in the stretching control group. The primary outcome measure was the Adult Myopathy Assessment Tool (<jats:styled-content style=\"fixed-case\">AMAT<\/jats:styled-content>) total score, and secondary measures included total activity by accelerometry, muscle strength, balance, timed up and go, sit\u2010to\u2010stand test, health\u2010related quality of life, creatine kinase, and insulin\u2010like growth factor\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Functional exercise was well tolerated but did not lead to significant group differences in the primary outcome measure or any of the secondary measures. The functional exercise did not produce significantly more adverse events than stretching, and was not perceived to be difficult. To determine whether a subset of the subjects may have benefited, we divided them into high and low functioning based on baseline <jats:styled-content style=\"fixed-case\">AMAT<\/jats:styled-content> scores and performed a post hoc subgroup analysis. Low\u2010functioning individuals receiving the intervention increased <jats:styled-content style=\"fixed-case\">AMAT<\/jats:styled-content> functional subscale scores compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Although these trial results indicate that functional exercise had no significant effect on total <jats:styled-content style=\"fixed-case\">AMAT<\/jats:styled-content> scores or on mobility, strength, balance, and quality of life, post hoc findings indicate that low\u2010functioning men with <jats:styled-content style=\"fixed-case\">SBMA<\/jats:styled-content> may respond better to functional exercises, and this warrants further investigation with appropriate exercise intensity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.208","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T07:22:08Z","timestamp":1430983328000},"page":"739-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A randomized controlled trial of exercise in spinal and bulbar muscular atrophy"],"prefix":"10.1002","volume":"2","author":[{"given":"Joseph A.","family":"Shrader","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Department Clinical Center National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Kats","sequence":"additional","affiliation":[{"name":"Neurogenetics Branch National Institute of Neurological Disorders and Stroke Bethesda 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