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The typical presentation involves the subacute development of pancerebellar deficits with a clinical plateau within 6 months. The vast majority of cases have been reported in women with pelvic or breast tumors. Magnetic resonance imaging of the brain is often normal in the early stages, with cerebellar atrophy seen later. The underlying mechanism is believed to be an immunological reaction to cerebellar degeneration\u2010related protein 2 (\n                    <jats:styled-content style=\"fixed-case\">CDR<\/jats:styled-content>\n                    2), a protein usually found in the cerebellum that is ectopically produced by tumor cells. Although both B\u2010 and T\u2010cell abnormalities are seen, there is debate about the relative importance of the autoantibodies and cytotoxic T lymphocytes in the neuronal loss. Cerebrospinal fluid abnormalities, primarily elevated protein, lymphocytic pleocytosis, and oligoclonal bands, are common in the early stages. The low prevalence of this condition has not allowed for large\u2010scale randomized controlled trials. Immunotherapies, such as steroids, intravenous immune globulins, and plasma exchange, have been extensively used in managing this condition, with limited success. Although some reports indicate benefit from antitumor therapies like surgery and chemotherapy, this has not been consistently observed. The prognosis for anti\u2010Yo\n                    <jats:styled-content style=\"fixed-case\">PCD<\/jats:styled-content>\n                    is almost uniformly poor, with most patients left bedridden. Further studies are required to clarify the pathophysiology and provide evidence\u2010based treatment options.\n                  <\/jats:p>","DOI":"10.1002\/acn3.328","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T07:42:41Z","timestamp":1467272561000},"page":"655-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Paraneoplastic cerebellar degeneration with anti\u2010Yo antibodies \u2013 a review"],"prefix":"10.1002","volume":"3","author":[{"given":"Anand","family":"Venkatraman","sequence":"first","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Opal","sequence":"additional","affiliation":[{"name":"Davee department of Neurology Northwestern University Feinberg School of Medicine Chicago Illinois"},{"name":"Department of Cell and Molecular Biology Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0356-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01266.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0967-5868(95)90052-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034447"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285609349521"},{"key":"e_1_2_8_7_1","first-page":"725936","article-title":"Anti\u2010yo associated paraneoplastic cerebellar degeneration in a man with large cell cancer of the lung","volume":"2013","author":"Hasadsri L","year":"2013","journal-title":"Case Rep Neurol Med."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00467-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(20010201)49:2<253::AID-ANA47>3.0.CO;2-3"},{"key":"e_1_2_8_10_1","first-page":"674","article-title":"Kenntnis der chronischen diffusen Kleinhirnerkrankungen","volume":"38","author":"Brouwer B. 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