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Across brain regions, we observed an interactive effect of beta\u2010amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta\u2010amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of A<jats:italic>\u03b2<\/jats:italic> and tau to neurodegeneration in Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/acn3.339","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T15:23:24Z","timestamp":1476977004000},"page":"934-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease"],"prefix":"10.1002","volume":"3","author":[{"given":"G\u00e9rard N.","family":"Bischof","sequence":"first","affiliation":[{"name":"Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany"},{"name":"Cognitive Neuroscience Institute of Neuroscience and Medicine (INM\u20103) Research Center J\u00fclich J\u00fclich 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