{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:18:04Z","timestamp":1777285084797,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI375"],"award-info":[{"award-number":["KLI375"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> parameters of iron concentration (R2*, transverse relaxation rate), microstructural integrity (mean diffusivity and fractional anisotropy), as well as gray and white matter volumes were analyzed in patients with subarachnoid hemorrhage (<jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>) and uncomplicated clinical course to detect the evolution of brain tissue changes 3 weeks and 12 months after ictus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scans of 14 <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content> patients (aneurysm of the anterior communicating artery, <jats:italic>n<\/jats:italic> = 5; no aneurysm <jats:italic>n<\/jats:italic> = 9) were compared with 14 age\u2010matched healthy control subjects. Statistical parametric mapping (<jats:styled-content style=\"fixed-case\">SPM<\/jats:styled-content>) was applied to objectively identify focal changes of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> parameters throughout the entire brain and to correlate image parameters with neuropsychological measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SPM<\/jats:styled-content> localized significant bilateral increases in R2* signal within the white matter compartment of the temporal and parietal lobe and the cingulate gyrus (<jats:italic>P<\/jats:italic> &lt; 0.001) which did not change significantly at 12 months. Significant gray matter volume reduction of the left insula and superior temporal gyrus (<jats:italic>P<\/jats:italic> &lt; 0.001), as well as decreases in fractional anisotropy of the cingulate gyrus (<jats:italic>P<\/jats:italic> &lt; 0.01) were also evident at 12 months. Significant correlations were found between fractional anisotropy signal alterations adjacent to the left middle and superior frontal gyrus and cognitive parameters of executive dysfunction (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The study indicates that iron is trapped predominantly throughout large portions of the white matter compartment in <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content> patients at 12 months postbleeding. Increased disintegration of fiber tracts colocalizing with iron overload and correlating with lower executive function performance suggests that the white matter compartment is primarily susceptible toward long\u2010term damage in patients with good clinical grade <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.341","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T10:30:52Z","timestamp":1472725852000},"page":"781-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Longitudinal profile of iron accumulation in good\u2010grade subarachnoid hemorrhage"],"prefix":"10.1002","volume":"3","author":[{"given":"Christoph","family":"Scherfler","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"},{"name":"Neuroimaging Research Core Facility Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alois Josef","family":"Schiefecker","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarete","family":"Delazer","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronny","family":"Beer","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bodner","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Spinka","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Kofler","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Pfausler","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kremser","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Core Facility Medical University of Innsbruck Innsbruck Austria"},{"name":"Department of Radiology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schocke","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Benke","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke R.","family":"Gizewski","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Core Facility Medical University of Innsbruck Innsbruck Austria"},{"name":"Department of Neuroradiology Medical University of Innsbruck Anichstrasse 35 A\u20106020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Schmutzhard","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimund","family":"Helbok","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.581975"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs0102.101080"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70017-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199312000-00007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150070074"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2002.000414"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-013-0489-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0552-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9605-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182587839"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346087"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_8_14_1","volume-title":"Hospital anxiety and depression scale \u2010 German version (HADS\u2010D)","author":"Hermann C","year":"1995"},{"key":"e_1_2_8_15_1","volume-title":"Verbaler Lern\u2010und merkf\u00e4higkeitstest","author":"Helmstaedter C","year":"2001"},{"key":"e_1_2_8_16_1","volume-title":"Rey complex figure test and recognition trial","author":"Meyers JE","year":"1995"},{"key":"e_1_2_8_17_1","volume-title":"Regensburger wortfl\u00fcssigkeits\u2010test (RWT)","author":"Aschenbrenner S","year":"2001"},{"key":"e_1_2_8_18_1","volume-title":"WMS\u2010R wechsler ged\u00e4chtnistest \u2013 revidierte fassung","author":"H\u00e4rting C","year":"2000"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.5.588"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6177(03)00039-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6929-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030303"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13825585.2015.1027650"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20698"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.029"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100495"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000075771.88719.CE"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355897"},{"key":"e_1_2_8_31_1","first-page":"1","article-title":"Detection of aneurysmal subarachnoid hemorrhage 3 months after initial bleeding: evaluation of T2* and FLAIR MR sequences at 3T in comparison with initial non\u2010enhanced CT as a gold standard","author":"Mule S","year":"2015","journal-title":"J. Neurointerv. Surg."},{"key":"e_1_2_8_32_1","first-page":"208","volume-title":"Greenfield's neuropathology","author":"Weller RO","year":"1984"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.51.275"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199803000-00004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.137"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90326-G"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.2.0287"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03268-7"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600143"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600399"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005307"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv180"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307326"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.7.1104"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-179"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.06.035"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2010.00645.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211002481"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307711"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facn3.341","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:17:46Z","timestamp":1696601866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/acn3.341"],"URL":"https:\/\/doi.org\/10.1002\/acn3.341","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"2016-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}