{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:18:23Z","timestamp":1786976303447,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["091593\/Z\/10\/Z"],"award-info":[{"award-number":["091593\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["515103"],"award-info":[{"award-number":["515103"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The distribution of pathology in neurodegenerative disease can be predicted by the organizational characteristics of white matter in healthy brains. However, we have very little evidence for the impact these pathological changes have on brain function. Understanding any such link between structure and function is critical for understanding how underlying brain pathology influences the progressive behavioral changes associated with neurodegeneration. Here, we demonstrate such a link between structure and function in individuals with premanifest Huntington's.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using diffusion tractography and resting state functional magnetic resonance imaging to characterize white matter organization and functional connectivity, we investigate whether characteristic patterns of white matter organization in the healthy human brain shape the changes in functional coupling between brain regions in premanifest Huntington's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We find changes in functional connectivity in premanifest Huntington's disease that link directly to underlying patterns of white matter organization in healthy brains. Specifically, brain areas with strong structural connectivity show decreases in functional connectivity in premanifest Huntington's disease relative to controls, while regions with weak structural connectivity show increases in functional connectivity. Furthermore, we identify a pattern of dissociation in the strongest functional connections between anterior and posterior brain regions such that anterior functional connectivity increases in strength in premanifest Huntington's disease, while posterior functional connectivity decreases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      Our findings demonstrate that organizational principles of white matter underlie changes in functional connectivity in premanifest Huntington's disease. Furthermore, we demonstrate functional antero\u2013posterior dissociation that is in keeping with the caudo\u2013rostral gradient of striatal pathology in\n                      <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.384","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T23:06:52Z","timestamp":1484608012000},"page":"106-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["White matter predicts functional connectivity in premanifest Huntington's disease"],"prefix":"10.1002","volume":"4","author":[{"given":"Peter","family":"McColgan","sequence":"first","affiliation":[{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology London WC1N 3BG United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gregory","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Neuroimaging UCL Institute of Neurology London WC1N 3BG United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel","family":"Razi","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Neuroimaging UCL Institute of Neurology London WC1N 3BG United Kingdom"},{"name":"Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Seunarine","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Biophysics Section UCL Institute of Child Health London WC1N 1EH United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Gargouri","sequence":"additional","affiliation":[{"name":"APHP Department of Genetics Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re and <i>ICM (Brain and Spine Institute)<\/i> INSERM U1127 CNRS UMR7225 Sorbonne Universit\u00e9s \u2013 UPMC Universit\u00e9 Paris VI UMR_S1127 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[{"name":"APHP Department of Genetics Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re and <i>ICM (Brain and Spine Institute)<\/i> INSERM U1127 CNRS UMR7225 Sorbonne Universit\u00e9s \u2013 UPMC Universit\u00e9 Paris VI UMR_S1127 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund A. 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