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Here, we investigate this interaction by analyzing sleep and tau pathology throughout tauopathy disease progression in P301S human tau transgenic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>P301S and wild\u2010type mice were analyzed by electroencephalography (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>)\/electromyography at 3, 6, 9, and 11 months of age for sleep\/wake time, <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> power, and homeostatic response. Cortical volume and tau pathology was also assessed by anti\u2010phospho\u2010tau <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>8 staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>P301S tau mice had significantly decreased rapid eye movement (<jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>) sleep at 9 months of age and decreased <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content>) sleep as well as increased wakefulness at 11 months. Sleep loss was characterized by fewer wake, <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content> bouts, increased wake bout duration, and decreased sleep bout duration. Decreased <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content> sleep was associated with increased brainstem tau pathology in the sublaterodorsal area and parafacial zone, respectively. P301S mice also showed increased <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> power at 6 and 9 months of age and decreased power at 11 months. Decreased <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> power was associated with decreased cortical volume. Despite sleep disturbances, P301S mice maintained homeostatic response to sleep deprivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our results indicate that tau pathology is associated with sleep disturbances that worsen with age and these changes may be related to tau pathology in brainstem sleep regulating regions as well as neurodegeneration. Tau\u2010induced sleep changes could affect disease progression and be a marker for therapeutic efficacy in this and other tauopathy models.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.390","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T05:12:58Z","timestamp":1487135578000},"page":"180-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Altered sleep and EEG power in the P301S Tau transgenic mouse model"],"prefix":"10.1002","volume":"4","author":[{"given":"Jerrah K.","family":"Holth","sequence":"first","affiliation":[{"name":"Department of Neurology Hope Center for Neurological Disorders, and the Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Mahan","sequence":"additional","affiliation":[{"name":"Department of Neurology Hope 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