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We evaluated a Malian family in which three individuals had <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content> and distal muscle atrophy and sensory loss. <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content> panel testing identified a novel heterozygous missense mutation in <jats:italic><jats:styled-content style=\"fixed-case\">KIF<\/jats:styled-content>5A<\/jats:italic> (c.1086G&gt;C, p.Lys362Asn) that segregated with the disease (<jats:styled-content style=\"fixed-case\">SPG<\/jats:styled-content>10). Lys362 is highly conserved across species and Lys362Asn is predicted to be damaging. This study shows that <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>s are present in sub\u2010Saharan Africa, although likely underdiagnosed. Increasing efficiency and decreasing costs of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> sequencing will make it more feasible to diagnose <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>s in developing countries.<\/jats:p>","DOI":"10.1002\/acn3.402","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T03:39:03Z","timestamp":1490153943000},"page":"272-275","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A novel mutation in <i>KIF5A<\/i> in a Malian family with spastic paraplegia and sensory loss"],"prefix":"10.1002","volume":"4","author":[{"given":"Cheick O.","family":"Guinto","sequence":"first","affiliation":[{"name":"Service de Neurologie Centre Hospitalier Universitaire du Point \u201cG\u201d Bamako 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