{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:52:28Z","timestamp":1790783548637,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Dutch MS Research Foundation","award":["08-650"],"award-info":[{"award-number":["08-650"]}]},{"name":"Dutch MS Research Foundation","award":["09-358d"],"award-info":[{"award-number":["09-358d"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n We conducted a multi\u2010modal optical coherence tomography (\n OCT<\/jats:styled-content>\n ) and magnetoencephalography (\n MEG<\/jats:styled-content>\n ) study to test whether there is a relationship between retinal layer integrity and electrophysiological activity and connectivity (\n FC<\/jats:styled-content>\n ) in the visual network influenced by optic neuritis (\n ON<\/jats:styled-content>\n ) in patients with multiple sclerosis (\n MS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n One hundred and two\n MS<\/jats:styled-content>\n patients were included in this\n MEG<\/jats:styled-content>\n \/\n OCT<\/jats:styled-content>\n study. Retinal\n OCT<\/jats:styled-content>\n data were collected from the optic discs, macular region, and segmented. Neuronal activity and\n FC<\/jats:styled-content>\n in the visual cortex was estimated from source\u2010reconstructed resting\u2010state\n MEG<\/jats:styled-content>\n data by computing relative power and the phase lag index (\n PLI<\/jats:styled-content>\n ). Generalized estimating equations (\n GEE<\/jats:styled-content>\n ) were used to account for intereye within\u2010patient dependencies.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was a significant relationship for both relative power and\n FC<\/jats:styled-content>\n in the visual cortex with retinal layer thicknesses. The findings were influenced by the presence of\n MSON<\/jats:styled-content>\n ,\n particularly<\/jats:italic>\n for connectivity in the alpha bands and the outer macular layers. In the absence of\n MSON<\/jats:styled-content>\n , this relationship was dominated by the lower frequency bands (theta, delta) and inner and outer retinal layers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These results suggest that visual cortex\n FC<\/jats:styled-content>\n more than activity alters in the presence of\n MSON<\/jats:styled-content>\n , which may guide the understanding of\n FC<\/jats:styled-content>\n plasticity effects following\n MSON<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acn3.415","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:08:39Z","timestamp":1501027719000},"page":"614-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Structure\u2010function relationships in the visual system in multiple sclerosis: an\n MEG<\/scp>\n and\n OCT<\/scp>\n study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3311-4990","authenticated-orcid":false,"given":"Prejaas","family":"Tewarie","sequence":"first","affiliation":[{"name":"Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands"},{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham Nottingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisanne J.","family":"Balk","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Hillebrand","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology and MEG Center Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn D.","family":"Steenwijk","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands"},{"name":"Department of Anatomy and Neurosciences Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard M. J.","family":"Uitdehaag","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis J.","family":"Stam","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology and MEG Center Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Petzold","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands"},{"name":"Department of Ophthalmology VU University Medical Center Amsterdam Netherlands"},{"name":"Moorfields Eye Hospital City Road London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/134858"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.108"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508088916"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.002"},{"key":"e_1_2_6_6_1","first-page":"2012","article-title":"Human optic nerve fiber count and optic disc size","volume":"33","author":"Jonas JB","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008455"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3476"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308189"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306902"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000532"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24351"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513518626"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr264"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.14.10"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(95)00313-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22596"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132708"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514538110"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034823"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002774"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20627"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20465"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.005"},{"key":"e_1_2_6_25_1","first-page":"e\u201069318","article-title":"Cognitive and clinical dysfunction, altered MEG resting\u2010state networks and thalamic atrophy in multiple sclerosis","author":"Tewarie P","year":"2013","journal-title":"8"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20346"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.907"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/WNO.0b013e3182a1e6aa","article-title":"OCT and NMO: are there methods to our madness?","volume":"33","author":"Balcer LJ","year":"2013","journal-title":"J Neuroophthalmol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.10.003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.057"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.897837"},{"key":"e_1_2_6_32_1","unstructured":"iscev. 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