{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:01:58Z","timestamp":1778583718667,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,10]],"date-time":"2017-12-10T00:00:00Z","timestamp":1512864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated the effects of deep brain stimulation (<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>) or lesions of the ventral intermediate nucleus (Vim) of the thalamus for spinocerebellar ataxia (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>) and examined the pathophysiological role of neuronal activity of the Vim underlying ataxia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five patients with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> with cortical atrophy (ages 60\u201069 years; 2 sporadic and three familial <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>) and five patients with essential tremor (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) (ages 57\u201371 years) were treated with Vim surgery. Intraoperatively, we recorded neuronal activity from single neurons in the Vim thalamus while patients were at rest and compared the physiological properties of those neurons between patients with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> and those with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postsurgery mean scores for the Fahn\u2013Tolosa\u2013Marin Tremor Scale were improved from 78 to 44 in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> patients and from 54 to 21 in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients. Stronger stimulation was necessary to optimize outcomes in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> as compared to <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients. We analyzed 68 Vim neurons in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> and 60 Vim neurons in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. Mean discharge rates, burst characteristics, and oscillatory activity were similar for both patient groups, however, we observed that the ratio of cells responding to passive manipulation was significantly smaller (<jats:italic>P<\/jats:italic> = 0.0001) in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> (22%) than in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> (71%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Thalamic surgery led to a significant improvement in tremor in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> patients. One potential mechanism underlying ataxia in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> may be disruption of cerebellar sensory feedback, which modulates motor commands in the cerebello\u2010thalamo\u2010cortical network.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.508","type":"journal-article","created":{"date-parts":[[2017,12,10]],"date-time":"2017-12-10T05:08:37Z","timestamp":1512882517000},"page":"52-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Neuronal activity and outcomes from thalamic surgery for spinocerebellar ataxia"],"prefix":"10.1002","volume":"5","author":[{"given":"Takao","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Neurology Aizawa Hospital Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abirami","family":"Muralidharan","sequence":"additional","affiliation":[{"name":"Neuromodulation Research Center Department of Neurology University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Brain Disease Research Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Yako","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Aizawa Hospital Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth B.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerrold L.","family":"Vitek","sequence":"additional","affiliation":[{"name":"Neuromodulation Research Center Department of Neurology University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/62.1.1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870070202"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.3.0296"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1056\/NEJM200002173420703","article-title":"A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor","volume":"342","author":"Schuuman PR","year":"2000","journal-title":"N Eng J Med"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0347"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-015-0692-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10192"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088159"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21338"},{"key":"e_1_2_9_11_1","article-title":"Deep brain stimulation for tremor associated with underlying ataxia syndromes: a case series and discussion of issues","author":"Oyama G","year":"2014","journal-title":"Tremor Other Hyperkinet Mov"},{"key":"e_1_2_9_12_1","volume-title":"The cerebellum","author":"Ito M","year":"2012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","DOI":"10.1113\/JP272769","article-title":"Jan 1. 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