{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:20:14Z","timestamp":1791872414942,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>ANO5<\/jats:italic>\u2010related myopathy is an important cause of limb\u2010girdle muscular dystrophy (LGMD) and hyperCKemia. The main descriptions have emerged from European cohorts, and the burden of the disease worldwide is unclear. We provide a detailed characterization of a large Brazilian cohort of <jats:italic>ANO5<\/jats:italic> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A national cross\u2010sectional study was conducted to describe clinical, histopathological, radiological, and molecular features of patients carrying recessive variants in <jats:italic>ANO5<\/jats:italic>. Correlation of clinical and genetic characteristics with different phenotypes was studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven patients from 34 nonrelated families with recessive mutations of <jats:italic>ANO5<\/jats:italic> were identified. The most common phenotype was LGMD, observed in 25 (67.5%) patients, followed by pseudometabolic presentation in 7 (18.9%) patients, isolated asymptomatic hyperCKemia in 4 (10.8%) patients, and distal myopathy in a single patient. Nine patients presented axial involvement, including one patient with isolated axial weakness. The most affected muscles according to MRI were the semimembranosus and gastrocnemius, but paraspinal and abdominal muscles, when studied, were involved in most patients. Fourteen variants in <jats:italic>ANO5<\/jats:italic> were identified, and the c.191dupA was present in 19 (56%) families. Sex, years of disease, and the presence of loss\u2010of\u2010function variants were not associated with specific phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>We present the largest series of anoctaminopathy outside Europe. The most common European founder mutation c.191dupA was very frequent in our population. Gender, disease duration, and genotype did not determine the phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.50801","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T07:38:36Z","timestamp":1560238716000},"page":"1225-1238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Clinical and molecular findings in a cohort of <i>ANO5<\/i>\u2010related myopathy"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-5878","authenticated-orcid":false,"given":"Andr\u00e9 M. 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