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We report the novel p.P397S <jats:italic>MAPT<\/jats:italic> variant in eight subjects from five apparently nonrelated families suffering from frontotemporal dementia with autosomal dominant pattern of inheritance. In silico analysis reported conflicting evidence of pathogenicity. The segregation analysis support that this variant is likely pathogenic. The mean age at onset (61.4\u00a0years) and mean disease duration (13.9\u00a0years) of these subjects and their affected relatives were significantly higher compared with our series of p.P301L <jats:italic>MAPT<\/jats:italic> mutation carriers. These findings suggest that p.P397S variant could be a new <jats:italic>MAPT<\/jats:italic> mutation associated with a less aggressive phenotype than other <jats:italic>MAPT<\/jats:italic> mutations.<\/jats:p>","DOI":"10.1002\/acn3.50844","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T13:39:41Z","timestamp":1563370781000},"page":"1559-1565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Novel P397S <i>MAPT<\/i> variant associated with late onset and slow progressive frontotemporal dementia"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-0010","authenticated-orcid":false,"given":"Sergi","family":"Borrego\u2010\u00c9cija","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic Institut d'Investigaci\u00f3 Biom\u00e8dica August Pi i Sunyer (IDIBAPS), 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