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We previously demonstrated that the reversible acetylcholinesterase inhibitor, Huperzine A, increases seizure resistance in <jats:italic>Scn1a<\/jats:italic> mutants. In the present study, we evaluated the therapeutic potential of donepezil, a\u00a0reversible acetylcholinesterase inhibitor\u00a0approved by the Food and Drug Administration, in a mouse model of Dravet syndrome (<jats:italic>Scn1a<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>). We found that donepezil conferred robust protection against induced seizures in <jats:italic>Scn1a<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mutants.<\/jats:p>","DOI":"10.1002\/acn3.50848","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T09:41:00Z","timestamp":1563874860000},"page":"1566-1571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0602-6351","authenticated-orcid":false,"given":"Jennifer C.","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Human Genetics Emory University Atlanta GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquelyn T.","family":"Thelin","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Emory 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