{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:24:32Z","timestamp":1784219072879,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Responsive neurostimulation (RNS) has emerged as an adjunctive treatment modality for patients with intractable focal epilepsy who are not surgical candidates or have more than one ictal onset focus. We report a 34\u2010year\u2010old patient with intractable, childhood\u2010onset, genetic generalized epilepsy (GGE) with tonic, atonic, myoclonic and absence seizures treated with RNS. Strip electrodes over the right posterior frontal cortex and depth electrodes placed in the right anterior nucleus were used for event detection and responsive stimulation. Two\u2010year follow\u2010up revealed 90\u201395% clinical seizure reduction. This case suggests that refractory GGE may be effectively treated with RNS targeting thalamocortical networks.<\/jats:p>","DOI":"10.1002\/acn3.50858","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T11:10:41Z","timestamp":1568200241000},"page":"2104-2109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Responsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-7011","authenticated-orcid":false,"given":"Aline","family":"Herlopian","sequence":"first","affiliation":[{"name":"MGH Epilepsy Service, Department of Neurology, Massachusetts General Hospital Harvard Medical School 55 Fruit St, ACC 739L Boston Massachusetts 02114"},{"name":"Department of Neurology, Yale Comprehensive Epilepsy Center Yale University School of Medicine 15 York St, LCI\u20107 New Haven 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