{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:08:59Z","timestamp":1790744939201,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008236","name":"Fondation Roger de Spoelberch","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009152","name":"Fondation Bertarelli","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009273","name":"Cogito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["140332"],"award-info":[{"award-number":["140332"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["140338"],"award-info":[{"award-number":["140338"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["146633"],"award-info":[{"award-number":["146633"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["33CM30\u2010124 089"],"award-info":[{"award-number":["33CM30\u2010124 089"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["51AU40\u2010125759"],"award-info":[{"award-number":["51AU40\u2010125759"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Depersonalization refers to the sensation of being detached from one\u2019s body, often associated with feelings of loss of control over one\u2019s own body, actions, or thoughts. Derealization refers to the altered perception of one\u2019s surroundings that is experienced as unreal. Although usually reported by psychiatric patients suffering from depression or anxiety, single case reports and small case series have described depersonalization\u2010 and derealization\u2010like symptoms in the context of epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We investigated the brain mechanisms of ictal depersonalization\u2013 and derealization like symptoms by analyzing clinical and neuropsychological data as well as the epileptogenic zone based on a multimodal approach in a group of patients reporting depersonalization\u2010 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a09) and derealization\u2010like symptoms (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07), from a single presurgical epilepsy center with focal epilepsy. We compared them with a group of control patients with experiential phenomena due to temporal lobe epilepsy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We show that all patients with ictal depersonalization\u2010like symptoms report altered self\u2010identification with their body and mostly suffer from frontal lobe epilepsy with the epileptogenic zone in the dorsal premotor cortex, while patients with derealization\u2010like symptoms suffer from temporal lobe epilepsy. This finding is supported by post\u2010ictal neuropsychological deficits, showing that depersonalization\u2010like symptoms were significantly more often associated with frontal lobe dysfunction as compared to the control patients and patients with derealization\u2010like symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We argue that depersonalization of epileptic origin constitutes a distinct disorder due to frontal lobe epilepsy. We discuss these findings with respect to earlier accounts of depersonalization and the recent concept of bodily self\u2010consciousness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.50870","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T19:28:30Z","timestamp":1566502110000},"page":"1739-1747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Depersonalization\u2010 and derealization\u2010like phenomena of epileptic origin"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-1300","authenticated-orcid":false,"given":"Lukas","family":"Heydrich","sequence":"first","affiliation":[{"name":"Laboratory of Cognitive Neuroscience Brain\u2010Mind Institute, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland"},{"name":"Department of Neurology University Hospital Geneva Geneva Switzerland"},{"name":"Core Lab, Psychosomatic Competence Center, Department of Neurology Inselspital, Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Marillier","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience Brain\u2010Mind Institute, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Evans","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience Brain\u2010Mind Institute, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margitta","family":"Seeck","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Blanke","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience Brain\u2010Mind Institute, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland"},{"name":"Department of Neurology University Hospital Geneva Geneva Switzerland"},{"name":"Center for Neuroprosthetics, School of Life Sciences Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Diagnostic and statistical manual of mental disorders: DSM\u2010IV","author":"DSM\u2010IV","year":"2000"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1935.tb01140.x"},{"key":"e_1_2_8_4_1","first-page":"530","article-title":"Separating depersonalisation and 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