{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:14:56Z","timestamp":1764260096971,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The comorbidity between multiple sclerosis (MS) and progressive familial intrahepatic cholestasis type\u20103 (PFIC3) has never been described yet. ABCB4 gene encodes the multidrug resistant protein 3 (MDR3) and its mutations induce PFIC3 as well as intrahepatic cholestasis of pregnancy (ICP) and drug\u2010induced liver injury (DILI). We describe the case of a 32\u2010year\u2010old female with MS and PFIC3 who was effectively treated with natalizumab and ursodeoxycholic acid (UCDA), in contrast to glatiramer acetate, dimethylfumarate, and IFNb1a associated with DILI. Our findings clarify the pharmacodynamics of MS therapies and suggest natalizumab plus UDCA as the effective treatment of PFIC3\/MS phenotype, unlike the others that should be avoided.<\/jats:p>","DOI":"10.1002\/acn3.50883","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:29:14Z","timestamp":1569907754000},"page":"2347-2350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Progressive familial intrahepatic cholestasis type\u20103 and multiple sclerosis: lessons from comorbidity"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-8112","authenticated-orcid":false,"given":"Roberto","family":"De Masi","sequence":"first","affiliation":[{"name":"Laboratory of Neuroproteomics Multiple Sclerosis Centre \u201cF. Ferrari\u201d Hospital 73042 Casarano \u2013 Lecce Italy"},{"name":"Complex Operative Unit of Neurology \u201cF. Ferrari\u201d Hospital 73042 Casarano \u2013 Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Orlando","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroproteomics Multiple Sclerosis Centre \u201cF. Ferrari\u201d Hospital 73042 Casarano \u2013 Lecce Italy"},{"name":"Laboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies University of the Salento Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"De Donno","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies University of the Salento Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.7224\/1537-2073.2016-086"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1038\/sj.ejhg.5201908"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1159\/000115967"},{"key":"e_1_2_6_5_1","first-page":"73","article-title":"Drug\u2010induced Liver Injury","volume":"6","author":"David S","year":"2010","journal-title":"US Gastroenterol Hepatol Rev"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1016\/j.msard.2015.08.008"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.50883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.50883","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.50883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:05:44Z","timestamp":1694210744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.50883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/acn3.50883"],"URL":"https:\/\/doi.org\/10.1002\/acn3.50883","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"type":"print","value":"2328-9503"},{"type":"electronic","value":"2328-9503"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"2019-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}