{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:21:59Z","timestamp":1790270519793,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The etiology of Guillain\u2010Barr\u00e9 syndrome (GBS) remains enigmatic, although genetic and environmental factors are speculated to be associated with this autoimmune condition. We investigated whether polymorphisms and the haplotype structures of the human leukocyte antigen (HLA)\u2010<jats:italic>DQB1<\/jats:italic> gene relate to the autoimmune response to infection and affect the development of GBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>HLA\u2010DQB1<\/jats:italic> polymorphic alleles (*0201, *030x, *0401, *050x, *060x) were determined for 151 Bangladeshi patients with GBS and 151 ethnically matched healthy controls using sequence\u2010specific polymerase chain reaction. Pairwise linkage disequilibrium (LD) and haplotype patterns were analyzed based on D \u0301statistics and the genotype package in R statistics, respectively. Association studies were conducted using Fisher's exact test and logistic regression analysis. The Bonferroni method was applied to correct for multiple comparisons, whereby the <jats:italic>P<\/jats:italic>\u2010value was multiplied with the number of comparisons and denoted as <jats:italic>P<\/jats:italic>c (<jats:italic>P<\/jats:italic>c, <jats:italic>P<\/jats:italic> corrected).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No associations were observed between <jats:italic>HLA\u2010DQB1<\/jats:italic> alleles and susceptibility to disease in the comparison between GBS patients and healthy subjects. Haplotype 9 (<jats:italic>DQB1<\/jats:italic>*0303\u2010*0601) tended to be less frequent among patients with GBS than healthy controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006, OR\u00a0=\u00a00.49, 95% CI\u00a0=\u00a00.30\u20130.82; <jats:italic>P<\/jats:italic>c\u00a0=\u00a00.06). Haplotype 5 (<jats:italic>DQB1<\/jats:italic>*0501\u2010*0602) and the <jats:italic>DQB1<\/jats:italic>*0201 alleles were more frequent in the <jats:italic>Campylobacter jejuni<\/jats:italic>\u2010triggered axonal variant of GBS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.024, OR\u00a0=\u00a04.06, 95% CI\u00a0=\u00a01.25\u201313.18; <jats:italic>P<\/jats:italic>c\u00a0=\u00a00.24) and demyelinating subtype (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.027, OR\u00a0=\u00a02.68, 95% CI\u00a0=\u00a01.17\u20136.17; <jats:italic>P<\/jats:italic>c\u00a0=\u00a00.35), though these associations were not significant after Bonferroni correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This study indicates that <jats:italic>HLA\u2010DQB1<\/jats:italic> polymorphisms are not associated with susceptibility to GBS. In addition, these genetic markers did not influence the clinical features or serological subgroup in patients with <jats:italic>C.\u00a0jejuni\u2010<\/jats:italic>triggered axonal variant of GBS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.50884","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T12:36:01Z","timestamp":1567168561000},"page":"1849-1857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Human leukocyte antigen\u2010<i>DQB1<\/i> polymorphisms and haplotype patterns in Guillain\u2010Barr\u00e9 syndrome"],"prefix":"10.1002","volume":"6","author":[{"given":"Shoma","family":"Hayat","sequence":"first","affiliation":[{"name":"Laboratory Sciences and Services Division (LSSD), icddr,b Dhaka 1212 Bangladesh"},{"name":"Department of Biochemistry and Molecular Biology University of Dhaka Dhaka 1000 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israt","family":"Jahan","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division (LSSD), icddr,b Dhaka 1212 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avizit","family":"Das","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division (LSSD), icddr,b Dhaka 1212 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Molecular Biology, Bangladesh University of Health Sciences (BUHS) Dhaka 1216 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakir Hossain","family":"Howlader","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Dhaka Dhaka 1000 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishtiaq","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Dhaka Dhaka 1000 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quazi","family":"Deen Mohammad","sequence":"additional","affiliation":[{"name":"National Institute of Neurosciences and Hospital Dhaka 1207 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-8079","authenticated-orcid":false,"given":"Zhahirul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division (LSSD), icddr,b Dhaka 1212 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0462"},{"key":"e_1_2_8_3_1","first-page":"381","article-title":"Guillain Barr\u00e9 syndrome","volume":"54","author":"Winer JB","year":"2001","journal-title":"Mol Pathol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.12.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043976"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.08.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-996-0033-5"},{"key":"e_1_2_8_8_1","first-page":"9","article-title":"Epidemiology of Campylobacter jejuni infections in the United States and other industrialized nations","author":"Tauxe RV","year":"1992","journal-title":"Campylobacter jejuni: Curr Status Futur Trends"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00201-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb02984.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.005015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2004.00327.x"},{"key":"e_1_2_8_13_1","first-page":"41","volume-title":"Immunobiology","author":"Janeway CA","year":"1997"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009143431106"},{"key":"e_1_2_8_15_1","first-page":"44","article-title":"HLA class II alleles are not a general susceptibility factor in Guillain\u2010Barr\u00e9 syndrome","volume":"11","author":"Geleijns K","year":"2005","journal-title":"AAN Enterp"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01229.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(95)00102-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00072-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3074"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.3.597"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440512"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.01.025"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141111"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.07.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12209"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.07.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cff735"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1993.tb01991.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1991.tb01872.x"},{"key":"e_1_2_8_31_1","first-page":"429","article-title":"HLA alleles in patients with Guillain\u2010Barre syndrome","volume":"113","author":"Li H","year":"2000","journal-title":"Chin Med J"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131374"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.12.1900"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920207783591690"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.2.379"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2015.1115212"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2004.tb00280.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2016-134724"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.50884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.50884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.50884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T10:54:08Z","timestamp":1694256848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.50884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/acn3.50884"],"URL":"https:\/\/doi.org\/10.1002\/acn3.50884","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,30]]},"assertion":[{"value":"2019-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}