{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:08:59Z","timestamp":1792714139801,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF\u20102013\u201002354884 and GR-2013-02355724"],"award-info":[{"award-number":["RF\u20102013\u201002354884 and GR-2013-02355724"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009878","name":"Regione del Veneto","doi-asserted-by":"publisher","award":["RP\u20102014\u201000000400"],"award-info":[{"award-number":["RP\u20102014\u201000000400"]}],"id":[{"id":"10.13039\/501100009878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We applied RT\u2010QuIC assay to detect \u03b1\u2010synuclein aggregates in cerebrospinal fluid (CSF) of patients with suspected Creutzfeldt\u2013Jakob disease who had a neuropathological diagnosis of dementia with Lewy bodies (DLB) (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a07), other neurodegenerative diseases with \u03b1\u2010synuclein mixed pathology (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020), or without Lewy\u2010related pathology (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a049). The test had a sensitivity of 92.9% and specificity of 95.9% in distinguishing \u03b1\u2010synucleinopathies from non\u2010\u03b1\u2010synucleinopathies. When performed in the CSF of patients with DLB (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a036), RT\u2010QuIC was positive in 17\/20 with probable DLB, 0\/6 with possible DLB, and 0\/10 with Alzheimer disease. These results indicate that RT\u2010QuIC for \u03b1\u2010synuclein is an accurate test for DLB diagnosis.\n                  <\/jats:p>","DOI":"10.1002\/acn3.50897","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T05:11:12Z","timestamp":1570684272000},"page":"2120-2126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["\u03b1\u2010Synuclein RT\u2010QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies"],"prefix":"10.1002","volume":"6","author":[{"given":"Matilde","family":"Bongianni","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona Policlinico G. B. Rossi Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ladogana","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Capaldi","sequence":"additional","affiliation":[{"name":"Biocrystallography Laboratory Department of Biotechnology University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Klotz","sequence":"additional","affiliation":[{"name":"Institute of Neurology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Baiardi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Cagnin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Perra","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona Policlinico G. B. Rossi Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-8716","authenticated-orcid":false,"given":"Michele","family":"Fiorini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona Policlinico G. B. Rossi Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Poleggi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-4393","authenticated-orcid":false,"given":"Giuseppe","family":"Legname","sequence":"additional","affiliation":[{"name":"Laboratory of Prion Biology Scuola Internazionale Superiore di Studi Avanzati (SISSA) Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Cattaruzza","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Medicine, Surgery and Health Sciences University Hospital and Health Services of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Janes","sequence":"additional","affiliation":[{"name":"Neurology Unit University of Udine Academic Hospital Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Tabaton","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties (DIMI) Unit of Geriatric Medicine University of Genova Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino","family":"Ghetti","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Monaco","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona Policlinico G. 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Rossi Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Institute of Neurology Medical University of Vienna Vienna Austria"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto Canada"},{"name":"Tanz Centre for Research in Neurodegenerative Disease Krembil Brain Institute Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-9524","authenticated-orcid":false,"given":"Piero","family":"Parchi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"},{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES) University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pocchiari","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5199-6264","authenticated-orcid":false,"given":"Gianluigi","family":"Zanusso","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona Policlinico G. 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