{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:05:30Z","timestamp":1790881530469,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop and validate a novel 14\u2010item self\u2010completed questionnaire (in English and German) enquiring about the presence of non\u2010motor symptoms (NMS) during the past month in patients with craniocervical dystonia in an international multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Dystonia Non\u2010Motor Symptoms Questionnaire (DNMSQuest) covers seven domains including sleep, autonomic symptoms, fatigue, emotional well\u2010being, stigma, activities of daily living, sensory symptoms. The feasibility and clinimetric attributes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 194 patients with CD (65.6% female, mean age 58.96\u00a0\u00b1\u00a012.17\u00a0years, duration of disease 11.95\u00a0\u00b1\u00a09.40\u00a0years) and 102 age\u2010 and sex\u2010matched healthy controls (66.7% female, mean age 55.67\u00a0\u00b1\u00a017.62\u00a0years) were collected from centres in Germany and the UK. The median total NMS score in CD patients was 5 (interquartile range 3\u20137), significantly higher than in healthy controls with 1 (interquartile range 0.75\u20132.25) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test). Evidence for intercorrelation and convergent validity is shown by moderate to high correlations of total DNMSQuest score with motor symptom severity (TWSTRS: <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.61), clinical global impression (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.40), and health\u2010related quality of life measures: CDQ\u201024 (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.74), EQ\u20105D index (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a0\u22120.59), and scale (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a0\u22120.49) (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Data quality and acceptability was very satisfactory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The DNMSQuest, a patient self\u2010completed questionnaire for NMS assessment in CD patients, appears robust, reproducible, and valid in clinical practice showing a tangible impact of NMS on quality of life in CD. As there is no specific, comprehensive, validated tool to assess the burden of NMS in dystonia, the DNMSQuest can bridge this gap and could easily be integrated into clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.50900","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T10:10:35Z","timestamp":1569579035000},"page":"2054-2065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Validation of a self\u2010completed Dystonia Non\u2010Motor Symptoms Questionnaire"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-6518","authenticated-orcid":false,"given":"Lisa","family":"Klingelhoefer","sequence":"first","affiliation":[{"name":"Department of Neurology Technical University Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallol R.","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"National Parkinson Foundation International Centre of Excellence Department of Neurology King\u2019s College Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kamm","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rostock Rostock Germany"},{"name":"German Centre for Neurodegenerative Diseases (DZNE) Rostock\/Greifswald Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Martinez\u2010Martin","sequence":"additional","affiliation":[{"name":"National Centre of Epidemiology and CIBERNED Carlos III Institute of Health Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Sobell Department of Motor Neuroscience and Movement Disorders UCL Institute of Neurology London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sauerbier","sequence":"additional","affiliation":[{"name":"National Parkinson Foundation International Centre of Excellence Department of Neurology King\u2019s College Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Neurology Technical University Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-0675","authenticated-orcid":false,"given":"Carmen","family":"Rodriguez\u2010Blazquez","sequence":"additional","affiliation":[{"name":"National Centre of Epidemiology and CIBERNED Carlos III Institute of Health Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Balint","sequence":"additional","affiliation":[{"name":"Sobell Department of Motor Neuroscience and Movement Disorders UCL Institute of Neurology London United Kingdom"},{"name":"Department of Neurology University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Untucht","sequence":"additional","affiliation":[{"name":"Department of Neurology Technical University Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynsey J.","family":"Hall","sequence":"additional","affiliation":[{"name":"National Parkinson Foundation International Centre of Excellence Department of Neurology King\u2019s College Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauritz","family":"Mildenstein","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rostock Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Wienecke","sequence":"additional","affiliation":[{"name":"Department of Neurology Technical University Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary &amp; 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