{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:35:31Z","timestamp":1789526131639,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671283"],"award-info":[{"award-number":["81671283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701266"],"award-info":[{"award-number":["81701266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To verify the utility of brain lesion distribution criteria in distinguishing multiple sclerosis (MS) from aquaporin\u20104 (AQP4)\u2010immunoglobulin G (IgG)\u2010positive\/\u2010negative neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein IgG\u2010associated encephalomyelitis (MOG\u2010EM) in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 253 patients with MS (80), NMOSD (129 AQP4\u2010IgG positive, 34 AQP4\u2010IgG negative), and MOG\u2010EM (10) were enrolled. Anonymized magnetic resonance imaging results were scored on the previous reported criteria of \u201cat least one lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe; or the presence of a subcortical U\u2010fiber lesion; or a Dawson\u2019s finger\u2010type lesion.\u201d Chi\u2010squared test (or Fisher\u2019s exact test) was used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution criteria were able to distinguish MS with a same sensitivity of 93.8% from all type of NMOSD and MOG\u2010EM, with a specificity of 89.7% from the whole NMOSD cohort, 89.1% from AQP4\u2010IgG\u2010positive NMOSD 91.2% from AQP4\u2010IgG\u2010negative NMOSD, and 70.0% from MOG\u2010EM. Dawson's finger\u2010type lesion was the most sensitive and specific feature, whereas the U\u2010fiber lesion was the least.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The brain lesion distribution criteria were helpful in distinguishing MS from NMOSD and MOG\u2010EM in the Chinese population. Dawson's finger\u2010type lesion was highly suggestive of MS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.50913","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:12:26Z","timestamp":1569903146000},"page":"2048-2053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Brain lesion distribution criteria distinguish demyelinating diseases in China"],"prefix":"10.1002","volume":"6","author":[{"given":"Meng\u2010Ting","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2010Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 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