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Recent evidence shows increased susceptibility to dyslipidemia and liver steatosis in patients. Here, we provide evidence that low fat diets nearly double survival in <jats:italic>Smn<jats:sup>2B\/\u2212<\/jats:sup><\/jats:italic> mice, a model for SMA, independent of changes in SMN levels, liver steatosis, or enhanced hepatic functions. Liver damage and ketone levels were reduced, implying a lower reliance on fatty acid oxidation. This preclinical proof of concept study provides grounds for controlled clinical investigation of dietary needs and offers evidence to inform nutritional guidelines specific to SMA.<\/jats:p>","DOI":"10.1002\/acn3.50920","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T04:29:28Z","timestamp":1571027368000},"page":"2340-2346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Low fat diets increase survival of a mouse model of spinal muscular atrophy"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3802-1195","authenticated-orcid":false,"given":"Marc\u2010Olivier","family":"Deguise","sequence":"first","affiliation":[{"name":"Regenerative Medicine Program Ottawa Hospital Research Institute Ottawa Ontario Canada K1H 8L6"},{"name":"Department of Cellular and Molecular Medicine University of Ottawa Ottawa Ontario Canada K1H 8M5"},{"name":"Centre 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