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Interictal spikes were localized, and TES targeted the cortical source of each subject's principal spike population. Targeted spikes were suppressed in five subject's (29\/35 treatment days overall), and nontargeted spikes were suppressed in four subjects. Epileptiform activity did not worsen. This study suggests that this protocol, designed to induce long\u2010term depression (LTD), is safe and effective in acute suppression of interictal epileptiform discharges.<\/jats:p>","DOI":"10.1002\/acn3.50934","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T09:33:41Z","timestamp":1573464821000},"page":"2579-2585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety of slow\u2010pulsed transcranial electrical stimulation in acute spike suppression"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6621-2848","authenticated-orcid":false,"given":"Mark D.","family":"Holmes","sequence":"first","affiliation":[{"name":"Regional Epilepsy Center Department of Neurology University of Washington Seattle 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