{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:56:58Z","timestamp":1772117818780,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NCCR Synapsy","award":["51NF40-185897"],"award-info":[{"award-number":["51NF40-185897"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The combination of congenital bilateral perisylvian syndrome (CBPS) with lower motor neuron dysfunction remains unusual and suggests a potential common genetic insult affecting basic neurodevelopmental processes. Here we identify a putatively pathogenic missense mutation in the\n                    <jats:italic>MCF2<\/jats:italic>\n                    gene in a boy with CBPS\n                    <jats:italic>.<\/jats:italic>\n                    Using in utero electroporation to genetically manipulate cortical neurons during corticogenesis, we demonstrate that the mouse\n                    <jats:italic>Mcf2<\/jats:italic>\n                    gene controls the embryonic migration of cortical projection neurons. Strikingly, we find that the CBPS\u2010associated\n                    <jats:italic>MCF2<\/jats:italic>\n                    mutation impairs cortical laminar positioning, supporting the hypothesis that alterations in the process of embryonic neuronal migration can lead to rare cases of CBPS.\n                  <\/jats:p>","DOI":"10.1002\/acn3.50949","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T11:24:06Z","timestamp":1576581846000},"page":"121-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>MCF2<\/i>\n                    is linked to a complex perisylvian syndrome and affects cortical lamination"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2552-9520","authenticated-orcid":false,"given":"Aude","family":"Molinard\u2010Chenu","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Geneva Medical School Geneva 4 CH\u20101211 Switzerland"},{"name":"Department of Basic Neurosciences University of Geneva Medical School Geneva 4 CH\u20101211 Switzerland"},{"name":"Institute of Genetics and Genomics in Geneva (IGe3) University of Geneva Medical Center (CMU) Geneva 4 CH\u20101211 Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00ebl","family":"Fluss","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit Pediatric Subspecialties Service University Hospitals of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sacha","family":"Laurent","sequence":"additional","affiliation":[{"name":"Service of Genetic Medicine University Hospitals of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9ryle","family":"Laurent","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Unit University Hospitals of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Guipponi","sequence":"additional","affiliation":[{"name":"Service of Genetic Medicine University Hospitals of Geneva Geneva Switzerland"},{"name":"Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre G.","family":"Dayer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Geneva Medical School Geneva 4 CH\u20101211 Switzerland"},{"name":"Department of Basic Neurosciences University of Geneva Medical School Geneva 4 CH\u20101211 Switzerland"},{"name":"Institute of Genetics and Genomics in Geneva (IGe3) University of Geneva Medical Center (CMU) Geneva 4 CH\u20101211 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