{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:50:57Z","timestamp":1790182257369,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T00:00:00Z","timestamp":1577232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44NS073188"],"award-info":[{"award-number":["R44NS073188"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the sensitivity of electrical impedance myography (EIM) to disease progression in both ambulatory and non\u2010ambulatory boys with DMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Participants<\/jats:title><jats:p>A non\u2010blinded, longitudinal cohort study of 29 ambulatory and 15 non\u2010ambulatory boys with DMD and age\u2010similar healthy boys. Subjects were followed for up to 1\u00a0year and assessed using the Myolex<jats:sup>\u00ae<\/jats:sup> mView<jats:sup>TM<\/jats:sup> EIM system as part of a multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the ambulatory group, EIM 100\u00a0kHz resistance values showed significant change compared to the healthy boys. For example, in lower extremity muscles, the average change in EIM 100\u00a0kHz resistance values over 12\u00a0months led to an estimated effect size of 1.58. Based on these results, 26 DMD patients\/arm would be needed for a 12\u2010month clinical trial assuming a 50% treatment effect. In non\u2010ambulatory boys, EIM changes were greater in upper limb muscles. For example, biceps at 100kHz resistance gave an estimated effect size of 1.92 at 12\u00a0months. Based on these results, 18 non\u2010ambulatory DMD patients\/arm would be needed for a 12\u2010month clinical trial assuming a 50% treatment effect. Longitudinal changes in the 100\u00a0kHz resistance values for the ambulatory boys correlated with the longitudinal changes in the timed supine\u2010to\u2010stand test. EIM was well\u2010tolerated throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This study supports that EIM 100\u00a0kHz resistance is sensitive to DMD progression in both ambulatory and non\u2010ambulatory boys. Given the technology\u2019s ease of use and broad age range of utility it should be employed as an exploratory endpoint in future clinical therapeutic trials in DMD.<\/jats:p><jats:p>Trial Registration: Clincialtrials.gov registration #NCT02340923<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.50958","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T04:25:48Z","timestamp":1577334348000},"page":"4-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Electrical impedance myography for reducing sample size in Duchenne muscular dystrophy trials"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-6125","authenticated-orcid":false,"given":"Melanie L.","family":"Leitner","sequence":"first","affiliation":[{"name":"Accelerating NeuroVentures LLC Needham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kush","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil T.","family":"Darras","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children\u2019s Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Children\u2019s Hospital Colorado Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dalle Pazze","sequence":"additional","affiliation":[{"name":"Charley\u2019s Fund New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julaine","family":"Florence","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Buck","sequence":"additional","affiliation":[{"name":"Myolex Inc Brookline Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Freedman","sequence":"additional","affiliation":[{"name":"Myolex Inc Brookline Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Bohorquez","sequence":"additional","affiliation":[{"name":"Myolex Inc Brookline Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seward","family":"Rutkove","sequence":"additional","affiliation":[{"name":"Myolex Inc Brookline Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Zaidman","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21544"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21808"},{"key":"e_1_2_7_4_1","first-page":"149","article-title":"The NorthStar Ambulatory Assessment in Duchenne muscular dystrophy: considerations for the design of clinical trials","volume":"87","author":"Ricotti V","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04345.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.11.014"},{"key":"e_1_2_7_7_1","unstructured":"McCuneS.Outcome measures biomarkers and endpoints. 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