{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T03:34:24Z","timestamp":1785641664693,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,8]],"date-time":"2019-12-08T00:00:00Z","timestamp":1575763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971070"],"award-info":[{"award-number":["81971070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX201820"],"award-info":[{"award-number":["ZYLX201820"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa\u2010induced dyskinesia (LID) in Parkinson\u2019s disease, and to explore the potential underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed clinical outcomes in 43 patients with preoperative LID who underwent DBS targeting the STN (20\/43) or GPi (23\/43). The primary clinical outcome was the change from baseline in the Unified Dyskinesia Rating Scale (UDysRS) and secondary outcomes included changes in the total daily levodopa equivalent dose, the drug\u2010off Unified Parkinson Disease Rating Scale Part \u2162 at the last follow\u2010up (median, 18\u00a0months), adverse effects, and programming settings. Correlation analysis was used to find potential associated factors that could be used to predict the efficacy of DBS for dyskinesia management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to baseline, both the STN group and the GPi group showed significant improvement in LID with 60.73\u00a0\u00b1\u00a040.29% (mean\u00a0\u00b1\u00a0standard deviation) and 93.78\u00a0\u00b1\u00a014.15% improvement, respectively, according to the UDysRS score. Furthermore, GPi\u2010DBS provided greater clinical benefit in the improvement of dyskinesia (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) compared to the STN. Compared to the GPi group, the levodopa equivalent dose reduction was greater in the STN group at the last follow\u2010up (43.81% vs. 13.29%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). For the correlation analysis, the improvement in the UDysRS outcomes were significantly associated with a reduction in levodopa equivalent dose in the STN group (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.543, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013), but not in the GPi group (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.056, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.801).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Both STN and GPi\u2010DBS have a beneficial effect on LID but GPi\u2010DBS provided greater anti\u2010dyskinetic effects. Dyskinesia suppression for STN\u2010DBS may depend on the reduction of levodopa equivalent dose. Unlike the STN, GPi\u2010DBS might exert a direct and independent anti\u2010dyskinesia effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.50961","type":"journal-article","created":{"date-parts":[[2019,12,8]],"date-time":"2019-12-08T23:30:15Z","timestamp":1575847815000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Pallidal versus subthalamic nucleus deep brain stimulation for levodopa\u2010induced dyskinesia"],"prefix":"10.1002","volume":"7","author":[{"given":"Shi\u2010Ying","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Functional Neurosurgery Beijing Neurosurgical Institute Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Neurostimulation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Beijing 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