{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:56:43Z","timestamp":1790107003153,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EU IAPP Program \u201cBRAINPATH\u201d","award":["612360"],"award-info":[{"award-number":["612360"]}]},{"name":"EU-funded FP7 \"EUROHEADPAIN\"","award":["6026337"],"award-info":[{"award-number":["6026337"]}]},{"name":"FP7","award":["2017-10"],"award-info":[{"award-number":["2017-10"]}]},{"name":"Dutch National Epilepsy Foundation","award":["2017-10"],"award-info":[{"award-number":["2017-10"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events \u2013 the electrophysiological correlate of the migraine aura \u2013 in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V\u2010mutated\n                    <jats:italic>\u03b1<\/jats:italic>\n                    1 subunits in voltage\u2010gated Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 sodium channels (\n                    <jats:italic>Scn1a<\/jats:italic>\n                    <jats:sup>L263V<\/jats:sup>\n                    ). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.\n                  <\/jats:p>","DOI":"10.1002\/acn3.50971","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T04:27:10Z","timestamp":1577420830000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["First FHM3 mouse model shows spontaneous cortical spreading depolarizations"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-054X","authenticated-orcid":false,"given":"Nico A.","family":"Jansen","sequence":"first","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisa","family":"Dehghani","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot M. 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