{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:14:56Z","timestamp":1788200096589,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007412","name":"Nippon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the benefits of a community\u2010based program combining physical exercise, cognitive training, and education on dementia and lifestyle habits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This crossover open\u2010label trial included 141 community\u2010dwelling elderly people with suspected mild cognitive decline (MCD). Subjects were assigned to a 6\u2010month intervention\u2010first\/6\u2010month observation\u2010second (INT\u2010OBS) group or an OBS\u2010INT group. The 6\u2010month intervention consisted of 2\u00a0h of physical exercise, cognitive training, and classroom study or rest once weekly. Primary outcome was change in Touch Panel\u2010type Dementia Assessment Scale (TDAS) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TDAS score improved significantly during the intervention period compared with the observation period for all subjects (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Some physical functions also improved significantly during the intervention period compared with the observation period in the OBS\u2010INT group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This community\u2010based program improved both cognitive and physical function in elderly people with suspected MCD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.50993","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T13:48:37Z","timestamp":1582033717000},"page":"318-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A program of exercise, brain training, and lecture to prevent cognitive decline"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-3254","authenticated-orcid":false,"given":"Minoru","family":"Kouzuki","sequence":"first","affiliation":[{"name":"Department of Biological Regulation School of Health Science Faculty of Medicine Tottori University 86, Nishi\u2010cho Yonago 683\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Medical Science in Sports and Exercise Department of Social Medicine Faculty of Medicine Tottori University 4\u2010101 Koyama\u2010cho Minami Tottori 680\u20108550 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Wada\u2010Isoe","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Brain and Neurological Sciences Faculty of Medicine Tottori University 36\u20101, Nichi\u2010cho Yonago 683\u20108504 Japan"},{"name":"Department of Dementia Research Kawasaki Medical School 2\u20106\u20101, Nakasange, Kita\u2010Ku Okayama 700\u20108505 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Tottori University Graduate School of Medical Sciences 86, Nishi\u2010cho Yonago 683\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhito","family":"Tamura","sequence":"additional","affiliation":[{"name":"The Nanbu Town National Health Insurance Saihaku Hospital 397, Yamato, Nanbu\u2010cho Saihaku 683\u20100323 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Takanashi","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapist YMCA College of Medical &amp; Human Services in Yonago 3\u20103\u20102, Kinkai\u2010cho Yonago Tottori 683\u20100825 Japan"},{"name":"Tottori Association of Occupational Therapists 3-3-2, Kinkai-cho Yonago Tottori 683-0825 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Azumi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Satoni Den\u2010en Clinic 54\u20102, Satoni Tottori\u2010shi Tottori 680\u20100935 Japan"},{"name":"Tottori Physical Therapy Association 212\u20105, Dakyojicho Kurayoshi 682\u20100816 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Kojima","sequence":"additional","affiliation":[{"name":"Social Welfare Corporation Kohen Nursing home Sakaikohen 2083, Seido\u2010cho Sakaiminato 684\u20100063 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Kotoura Town Hall 591\u20102, Tokuman, Kotoura\u2010cho Touhakugunn 689\u20102392 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Kotoura Town Hall 591\u20102, Tokuman, Kotoura\u2010cho Touhakugunn 689\u20102392 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michimi","family":"Itou","sequence":"additional","affiliation":[{"name":"Yonago Public Comprehensive Support Center for Shoutoku\u2010Community 1238 Ishii Yonago Tottori 683\u20100021 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Urakami","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation School of Health Science Faculty of Medicine Tottori University 86, Nishi\u2010cho Yonago 683\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-1528"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-1531"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60461-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022252"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b7849b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2709"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31363-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2011.00397.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317508330222"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2010.00345.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.11.1356"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.11.1567"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.03.038"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2935"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan8821"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2000.tb02654.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1675"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2017-209811"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015950108"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061483"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160276"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-1-201107050-00006"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facn3.50993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.50993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.50993","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.50993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:43:33Z","timestamp":1694051013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.50993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/acn3.50993"],"URL":"https:\/\/doi.org\/10.1002\/acn3.50993","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}