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Abnormal (elevated; A+) <jats:sup>11<\/jats:sup>C\u2010PiB\u2010PET retention ratio was defined as standardized uptake value ratio\u00a0\u2265\u00a01.48, and abnormal (reduced) AD signature cortical thickness as\u00a0\u2264\u00a02.68\u00a0mm (neurodegeneration; N+). Associations were examined with mixed effects models, adjusting for age, sex, education, apolipoprotein E \u03b54 allele carrier status, and global cognitive z\u2010score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age (SD) was 71.4\u00a0years (10.1), 46.7% were females, 195 (11.2%) had A+N\u2010, 442 (25.3%) had A\u2010N+, and 339 (19.4%) had A+N+ biomarkers. The A+N+ group had the largest annualized change in the FAQ score from baseline (difference in annual change A+N+ vs. A\u2010N\u2010; \u00df (SE): 0.80 (0.07)); associations were substantially attenuated when a time\u2010varying global cognitive composite was included in the model (A+N+ vs. A\u2010N\u2010; \u00df (SE): 0.31 (0.05)). CDR\u2010SOB (functional) findings partly agreed with FAQ score findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The longitudinal increase in functional limitations is greater for individuals with abnormal neuroimaging biomarkers, especially for those with both elevated brain amyloid and neurodegeneration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51010","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T07:40:15Z","timestamp":1587454815000},"page":"474-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain amyloid, cortical thickness, and changes in activities of daily living"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-136X","authenticated-orcid":false,"given":"Maria","family":"Vassilaki","sequence":"first","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah A.","family":"Aakre","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter K.","family":"Kremers","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G.","family":"Lesnick","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonas E.","family":"Geda","sequence":"additional","affiliation":[{"name":"Center for Bioelectronics and Biosensors Biodesign Institute, Arizona State University Tempe Arizona"},{"name":"Mayo Clinic Study of Aging Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"Machulda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-066X","authenticated-orcid":false,"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Butler","sequence":"additional","affiliation":[{"name":"Personalized Health Care\u2010Data Science and Product Development Medical Affairs F. 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