{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:58:13Z","timestamp":1792166293944,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. 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Eight neuropsychiatric symptoms studied increased in absolute prevalence by 6.2\u201320.9% at year 5 relative to baseline, and cognitive impairment increased by 2.7\u20136.2%. In comparison, the frequency of neuropsychiatric symptoms in healthy controls remained stable or declined over time. Antidepressant and anxiolytic\/hypnotic use in Parkinson disease were common at baseline and increased over time (18% to 27% for the former; 13% to 24% for the latter); antipsychotic and cognitive\u2010enhancing medication use was uncommon throughout (2% and 5% of patients at year 5); and potentially harmful anticholinergic medication use was common and increased over time. At year 5 the cross\u2010sectional prevalence for having three or more neuropsychiatric disorders\/cognitive impairment was 56% for Parkinson disease participants versus 13% for healthy controls, and by then seven of the examined disorders had either occurred or been treated at some time point in the majority of Parkinson disease patients. Principal component analysis suggested an affective disorder subtype only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Neuropsychiatric features in Parkinson disease are common from the onset, increase over time, are frequently comorbid, and fluctuate in severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51022","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T02:53:40Z","timestamp":1586832820000},"page":"449-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-7168","authenticated-orcid":false,"given":"Daniel","family":"Weintraub","sequence":"first","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Parkinson\u2019s Disease Research, Education and Clinical Center Philadelphia Veterans Affairs Medical Center Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Caspell\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Simuni","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunkeun R.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King\u2019s College London London England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-4875","authenticated-orcid":false,"given":"Roy N.","family":"Alcalay","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Vagelos College of Physicians and Surgeons New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Neurology Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana M.","family":"Chahine","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Eberling","sequence":"additional","affiliation":[{"name":"Michael J. 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