{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:26:18Z","timestamp":1791195978554,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000295","name":"Epilepsy Research UK","doi-asserted-by":"publisher","award":["F1301"],"award-info":[{"award-number":["F1301"]}],"id":[{"id":"10.13039\/501100000295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug\u2010refractory pediatric epilepsy. Perampanel (PER) is a non\u2010competitive AMPAR antagonist, and pre\u2010clinical studies have shown the AMPAR\u2010mediated anticonvulsant effects of decanoic acid (DEC), a major medium\u2010chain fatty acid provided in the medium\u2010chain triglyceride ketogenic diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using brain tissue resected from children with intractable epilepsy, we recorded the effects of PER and DEC in vitro<jats:italic>.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found resected pediatric epilepsy tissue exhibits spontaneous epileptic activity in vitro, and showed that DEC and PER inhibit this epileptiform activity in local field potential recordings as well as excitatory synaptic transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This study confirms AMPAR antagonists inhibit epileptiform discharges in brain tissue resected in a wide range of pediatric epilepsies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51030","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T12:16:47Z","timestamp":1589890607000},"page":"883-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-3779","authenticated-orcid":false,"given":"Sukhvir K.","family":"Wright","sequence":"first","affiliation":[{"name":"Aston Neuroscience Institute School of Life and Health Sciences Aston University Birmingham UK"},{"name":"Department of Paediatric Neurology The Birmingham Women\u2019s and Children's Hospital NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max 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