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Here, in a group of patients with mesial temporal lobe epilepsy (mTLE), we seek to confirm these EEG features, and using simultaneous functional magnetic resonance imaging, we investigate whether brain networks related to the alpha rhythm differ between patients and healthy controls. Additionally, we investigate whether alpha abnormalities are found as an inherited endophenotype in asymptomatic relatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We acquired scalp EEG and simultaneous EEG and functional magnetic resonance imaging in 24 unrelated patients with unilateral mTLE, 23 asymptomatic first\u2010degree relatives of patients with mTLE, and 32 healthy controls. We compared peak alpha power and frequency from electroencephalographic data in patients and relatives to healthy controls. We identified brain networks associated with alpha oscillations and compared these networks in patients and relatives to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients had significantly reduced peak alpha frequency (PAF) across all parietal and occipital\u00a0electrodes. Asymptomatic relatives also had significantly reduced PAF over 14 of 17 parietal and occipital\u00a0electrodes. Both patients and asymptomatic relatives showed a combination of increased activation and a failure of deactivation in relation to alpha oscillations compared to healthy controls in the sensorimotor network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Genetic factors may contribute to the shift in PAF and alterations in brain networks related to alpha oscillations. These may not entirely be a consequence of anti\u2010epileptic drugs, seizures or hippocampal sclerosis and deserve further investigation as mechanistic contributors to mTLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51032","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T05:41:10Z","timestamp":1587793270000},"page":"667-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Heritability of alpha and sensorimotor network changes in temporal lobe epilepsy"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-1973","authenticated-orcid":false,"given":"Siti N.","family":"Yaakub","sequence":"first","affiliation":[{"name":"Department of Basic &amp; Clinical Neuroscience Institute of Psychiatry King\u2019s College London Psychology &amp; Neuroscience London UK"},{"name":"School of Biomedical Engineering &amp; Imaging Sciences King\u2019s College London &amp; Guy\u2019s and St Thomas\u2019 PET Centre King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-0767","authenticated-orcid":false,"given":"Chayanin","family":"Tangwiriyasakul","sequence":"additional","affiliation":[{"name":"Department of Basic &amp; Clinical Neuroscience Institute of Psychiatry King\u2019s College London Psychology &amp; Neuroscience London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-1450","authenticated-orcid":false,"given":"Eugenio","family":"Abela","sequence":"additional","affiliation":[{"name":"Department of Basic &amp; Clinical Neuroscience Institute of Psychiatry King\u2019s College London Psychology &amp; Neuroscience London UK"},{"name":"Department of Clinical Neurophysiology King\u2019s College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalis","family":"Koutroumanidis","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology and Epilepsies Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust St. Thomas\u2019 Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D. 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