{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:53:15Z","timestamp":1781880795285,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107\u20102314\u2010B\u2010038\u2010078\u2010"],"award-info":[{"award-number":["107\u20102314\u2010B\u2010038\u2010078\u2010"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108\u20102314\u2010B\u2010038\u2010049\u2010"],"award-info":[{"award-number":["108\u20102314\u2010B\u2010038\u2010049\u2010"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study investigates the peripheral neuropathy in Primary Sj\u00f6gren's syndrome (pSS) using the nerve excitability test to further elucidate how peripheral nerves are affected by the autoantibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Each patient received clinical evaluation, examination for anti\u2010SSA\/Ro and anti\u2010SSB\/La antibodies titer, paired motor and sensory nerve excitability test, thermal quantitative sensory test (QST), and nerve conduction study (NCS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 40 pSS patients wasenrolled. Motor axonal study of the pSS with positive anti\u2010SSA\/Ro or anti\u2010SSB\/La antibodies (<jats:italic>n<\/jats:italic>\u00a0=\u00a028) was found to have increased stimulus for 50% compound muscle action potential (CMAP) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), increased rheobase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), increased minimum I\/V slope (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and hyperpolarizing I\/V slope (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), increased relative refractory period (RRP, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), decreased accommodation of threshold electrotonus toward depolarizing current (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), and increased accommodation toward hyperpolarizing current (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Seronegative pSS (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) showed much less prominent motor axonal changes, showing only increased minimum I\/V slope (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Sensory axonal study in seropositive pSS patients is found to have increased stimulus for 50% sensory nerve action potential (SNAP) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), decreased latency (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), increased RRP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and increased subexcitability (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Seronegative pSS patients have shown no significant sensory axonal changes. Thermal QST showed more prominent abnormalities in seronegative pSS compared to seropositive pSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Anti\u2010SSA\/Ro and anti\u2010SSB\/La autoantibodies might cause dysfunction in nodal and internodal region of the axon and small nerve fibers; meanwhile, autoreactive antibodies in seronegative pSS mainly affect small nerve fibers. Thus, the underlying pathophysiology for the two types of pSS is different.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51053","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T11:15:08Z","timestamp":1589627708000},"page":"819-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Immune\u2010mediated axonal dysfunction in seropositive and seronegative primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9979-6779","authenticated-orcid":false,"given":"Jowy","family":"Tani","sequence":"first","affiliation":[{"name":"Department of Neurology Wan Fang Hospital Taipei Medical University Taipei Taiwan"},{"name":"Ph.D. Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-4840","authenticated-orcid":false,"given":"Hsien\u2010Tzung","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine College of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1093-6019","authenticated-orcid":false,"given":"Hui\u2010Ching","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-2791","authenticated-orcid":false,"given":"Lung\u2010Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui\u2010San","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-7369","authenticated-orcid":false,"given":"Cindy","family":"Shin\u2010Yi Lin","sequence":"additional","affiliation":[{"name":"Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei Taiwan"},{"name":"Central Clinical School Faculty of Medicine and Health Brain &amp; 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