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We aimed to investigate neuronal and astroglial markers in patients with multiple sclerosis (MS) and aquaporin\u20104 antibody\u2010seropositive neuromyelitis optica spectrum disorders (NMOSD) to compare the clinical implications of these markers according to age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using single\u2010molecule array assays, we measured neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in sera from consecutive patients with MS (n\u00a0=\u00a0117) and NMOSD (n\u00a0=\u00a063). For each disease, we assessed correlations between these markers and disease severity (Expanded Disability Status Scale [EDSS]) scores according to three age groups (\u226444, 45\u201354, and\u00a0\u226555\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although serum GFAP levels were significantly higher in patients with NMOSD than those with MS, levels of both serum markers revealed significant positive correlations with EDSS scores in both diseases. In MS patients, the degrees of correlation between serum NfL (or GFAP) levels and EDSS scores were similar across all age groups. However, in NMOSD patients, positive GFAP\u2010EDSS correlations were distinctively stronger in the youngest than in the oldest group. Conversely, there were no positive NfL\u2010EDSS correlations in NMOSD in the youngest group, but there were significant in the oldest group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The degrees to which serum NfL and GFAP levels reflect disease severity vary significantly with patient age in NMOSD, but not in MS. These findings suggest that the pathological processes and progression differ between the diseases; hence, serum biomarker levels may need to be interpreted differently according to patient age and disease type.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51070","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T08:09:47Z","timestamp":1591258187000},"page":"992-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Clinical implication of serum biomarkers and patient age in inflammatory demyelinating diseases"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-1029","authenticated-orcid":false,"given":"Eun\u2010Jae","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"},{"name":"Department of Medicine Asan Medical Institute of Convergence 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