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Compared with <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT, <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT has superior tracer kinetics. We aimed to conduct a meta\u2010analysis to assess the efficacy of using <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT positron emission tomography (PET) and <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT single\u2010photon emission computed tomography (SPECT) of dopamine transporters in patients with PD in order to provide evidence for clinical decision\u2010making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed, Embase, Wanfang Data, and China National Knowledge Infrastructure databases to identify the relevant studies from the time of inception of the databases to 30 April 2020. We identified six PET studies, including 779 patients with PD and 124 healthy controls, which met the inclusion criteria. Twenty\u2010seven SPECT studies with 1244 PD patients and 859 controls were also included in this meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall effect\u2010size analysis indicated that patients with PD showed significantly reduced <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT uptake in three brain regions [caudate nucleus: standardized mean difference (SMD)\u00a0=\u00a0\u22121.71, <jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u22123.31, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0009; anterior putamen: SMD\u00a0=\u00a0\u22123.71, <jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u22126.26, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001; and posterior putamen: SMD\u00a0=\u00a0\u22125.49, <jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u22125.97, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001]. Significant decreases of <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT uptake were also observed in the caudate (SMD\u00a0=\u00a0\u22122.31, <jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u221211.49, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and putamen (SMD\u00a0=\u00a0\u22123.25, <jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u221214.79, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In conclusion, our findings indicate that both <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET and <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT imaging of dopamine transporters can provide viable biomarkers for early PD diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51122","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T21:28:12Z","timestamp":1597440492000},"page":"1524-1534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Imaging of dopamine transporters in Parkinson disease: a meta\u2010analysis of <sup>18<\/sup>F\/<sup>123<\/sup>I\u2010FP\u2010CIT studies"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-5683","authenticated-orcid":false,"given":"Yanyan","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Center for Functional Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China"},{"name":"PET Center Huashan Hospital Fudan University Shanghai 200235 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