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The mean age at onset was 69.5\u00a0\u00b1\u00a08.8\u00a0years (range 37\u201095) and the mean duration of the symptoms was 10.5\u00a0\u00b1\u00a04.2\u00a0years. The association between symptoms duration and HS and TDP\u201043 was examined with logistic regression analyses controlling for age at death, atherosclerosis in the Circle of Willis (CW), cerebral infarcts, gender, baseline Mini Mental State Examination scores, APOE\u20104 allele, and presence of Lewy bodies (LB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HS was present in 18% (n\u00a0=\u00a064) and TDP\u201043 in 51.5% (n\u00a0=\u00a0185) of the patients. HS and TDP\u201043 were more frequent in patients whose symptoms lasted more than 10\u00a0years. LBs were present in 72% of the patients with HS and in 64% of the patients with TDP\u201043. Age at onset was not associated with TDP\u201043 or HS. HS was associated with duration of symptoms and LB, TDP\u201043, and atherosclerosis in the CW. TDP\u201043 was associated with duration of symptoms, LB, and HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>HS and TDP\u201043 are present in early and late onset AD. However, their presence is mainly driven by the duration of symptoms and the presence of LB. This suggests that HS and TDP\u201043 are part of the later neuropathological changes in AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51135","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T11:05:32Z","timestamp":1596193532000},"page":"1546-1556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hippocampal sclerosis, TDP\u201043, and the duration of the symptoms of dementia of AD patients"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-8256","authenticated-orcid":false,"given":"Oscar L.","family":"Lopez","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"},{"name":"Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kofler","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YueFang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B.","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"},{"name":"Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"},{"name":"Department of Psychology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Sweet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelesh","family":"Nadkarni","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhi","family":"Patira","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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