{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:15:13Z","timestamp":1786976113951,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. 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The primary outcome measures were specific demographic and clinical features of Parkinson\u2019s disease, including age at onset, disease progression, survival, motor signs, dementia, dystonia, dyskinesia, autonomic dysfunction, impulse control disorder, psychiatric features, REM sleep behavior disorder, restless legs syndrome, and Parkinson\u2019s disease subtype. Specific clinical features were measured at the initial visit and most recent visit. These outcomes were assessed for association with\n                      <jats:italic>MAPT<\/jats:italic>\n                      H1 subhaplotypes, which were defined by six haplotype tagging variants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median onset age was 64\u00a0years (range: 22\u201094\u00a0years); 548 (64%) of patients were male. Significant associations (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0029) were observed between\n                      <jats:italic>MAPT<\/jats:italic>\n                      H1b and orthostatic hypotension (OR\u00a0=\u00a01.72,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001); between H1j and rest tremor (OR\u00a0=\u00a00.15;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) as well as REM sleep behavior disorder (OR\u00a0=\u00a03.87,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001); between H1r and bradykinesia (OR\u00a0=\u00a00.11;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001); and between H1v and restless legs syndrome (OR\u00a0=\u00a04.02,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      Four\n                      <jats:italic>MAPT<\/jats:italic>\n                      H1 subhaplotypes, but not the H2 haplotype, were significantly associated with specific clinical features in Parkinson\u2019s disease.\n                      <jats:italic>MAPT<\/jats:italic>\n                      haplotypic structure may explain some of the phenotypic variability in disease. Replication of our findings will be critical to fully resolve the Parkinson\u2019s disease risk association signal at Chr17q21.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51139","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T21:29:10Z","timestamp":1596835750000},"page":"1557-1563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of\n                    <i>MAPT<\/i>\n                    subhaplotypes with clinical and demographic features in Parkinson\u2019s disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Angela B.","family":"Deutschlander","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Jacksonville Florida"},{"name":"Department of Neuroscience Mayo Clinic Jacksonville 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