{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:31:14Z","timestamp":1788175874946,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71\u2010year\u2010old man with severe left\u2010sided tremor caused by a microbleed near the right red nucleus. Using accelerometry\u2010fMRI, we show tremor\u2010related activity in contralateral sensorimotor cortex and cerebellar vermis. This network was distinct from, but functionally coupled to, the Holmes lesion connectome. We propose that Holmes tremor involves three distinct cerebral mechanisms: a structural lesion, an intermediate lesion connectome, and symptom\u2010related activity.<\/jats:p>","DOI":"10.1002\/acn3.51143","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T08:01:25Z","timestamp":1596009685000},"page":"1453-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The cerebral tremor circuit in a patient with Holmes tremor"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5440-7533","authenticated-orcid":false,"given":"Freek","family":"Nieuwhof","sequence":"first","affiliation":[{"name":"Centre for Cognitive Neuroimaging Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob M.A.","family":"de Bie","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC \u2010 Locatie AMC Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Praamstra","sequence":"additional","affiliation":[{"name":"Department of Neurology Center of Expertise for Parkinson &amp; Movement Disorders Donders Institute for Brain, Cognition and Behaviour Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pepijn","family":"van den Munckhof","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Amsterdam UMC \u2010 Locatie AMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-6573","authenticated-orcid":false,"given":"Rick C.","family":"Helmich","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Neuroimaging Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen The Netherlands"},{"name":"Department of Neurology Center of Expertise for Parkinson &amp; Movement Disorders Donders Institute for Brain, Cognition and Behaviour Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27121"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv228"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25618"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22361"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.12.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz085"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000582"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz261"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.056"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0436-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3634-15.2016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602413113"},{"key":"e_1_2_8_15_1","unstructured":"FlandinG FristonKJ.Analysis of family\u2010wise error rates in statistical parametric mapping using random field theory. 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