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A statistical power analysis was performed across biomarkers and groups based on longitudinal mixed effects modeling and using several different clinical trial designs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For a 30\u2010month trial of preclinical AD, both the temporal composite and hippocampal volumes were superior to plasma neurofilament light and cognition. For an 18\u2010month trial of mild AD, hippocampal volume was superior to all other biomarkers. Plasma neurofilament light became more effective with increased trial duration or sampling frequency. Imaging biomarkers were characterized by high slope and low within\u2010subject variability, while plasma neurofilament light and cognition were characterized by higher within\u2010subject variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>MRI measures had properties that made them preferable to cognition and pNFL as outcome measures in clinical trials of early AD, regardless of cognitive status. However, pNfL and cognition can still be effective depending on inclusion criteria, sampling frequency, and response to therapy. Future trials will help to understand how sensitive pNfL and MRI are to detect downstream effects on neurodegeneration of drugs targeting amyloid and tau pathology in AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51158","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T02:16:45Z","timestamp":1597198605000},"page":"1661-1673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparing progression biomarkers in clinical trials of early Alzheimer\u2019s disease"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-3387","authenticated-orcid":false,"given":"Nicholas C.","family":"Cullen","sequence":"first","affiliation":[{"name":"Clinical Memory Research Unit Department of Clincal Sciences Malm\u00f6 Faculty of Medicine Lund University Lund 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