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There have been no studies investigating ablative treatments for the management of this disorder. Three patients underwent either a staged unilateral pallidotomy and contralateral pallidothalamic tractotomy (19\u2010year\u2010old man, 2\u2010year follow\u2010up), a unilateral pallidothalamic tractotomy (34\u2010year\u2010old man, 6\u2010month follow\u2010up) or a simultaneous unilateral pallidothalamic tractotomy and ventro\u2010oral thalamotomy (29\u2010year\u2010old man, 6\u2010month follow\u2010up). The average total patient score on the Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale\u2010Movement Scale improved from 39.5 to 13.2 (66.6%) after the procedures. No significant complications were identified. Ablative treatments appear to be a promising alternative surgical option for generalized dystonia with KMT2B mutation.<\/jats:p>","DOI":"10.1002\/acn3.51170","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T17:09:12Z","timestamp":1599239352000},"page":"2047-2051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Radiofrequency ablation for DYT\u201028 dystonia: short term follow\u2010up of three adult cases"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-3244","authenticated-orcid":false,"given":"Shiro","family":"Horisawa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Tokyo Women\u2019s Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenkou","family":"Azuma","sequence":"additional","affiliation":[{"name":"Tokyo Women\u2019s Medical University Institute for Integrated 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