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He had also developed stiffness in his neck and shoulders and uncontrollable muscle spasms. Exam was notable for ptosis, fatiguing weakness in extremities, increased tone, hyperreflexia with clonus, and spastic gait. A mediastinal mass was found on chest CT (Fig. 1), and biopsy confirmed an invasive thymoma with positive nodes. Serum testing was positive for antibodies to acetylcholine receptors as well as glutamic acid decarboxylase.<\/jats:p>","DOI":"10.1002\/acn3.51181","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T12:55:27Z","timestamp":1605099327000},"page":"2535-2537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The case of a 30\u2010year\u2010old man with subacute gait instability, weakness, and muscle spasms"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-5650","authenticated-orcid":false,"given":"Mitesh P.","family":"Mehta","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-9297","authenticated-orcid":false,"given":"Leonard L.","family":"Sokol","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"issue":"15","key":"e_1_2_2_2_1","first-page":"421","article-title":"Progressive fluctuating muscular rigidity and spasm (\"stiff\u2010man\" syndrome); report of a case and some observations in 13 other cases","volume":"31","author":"Moersch FP","year":"1956","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-009-0013-9"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-996-0006-8"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.036558"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260118"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199704)20:4<493::AID-MUS13>3.0.CO;2-#"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309201"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65339-7"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.991"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302253280805"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.07.019"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.02.076"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00602-5"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.51181","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T13:06:21Z","timestamp":1693832781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/acn3.51181"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51181","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"assertion":[{"value":"2020-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}