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We report the clinical and biochemical manifestations that were evaluated in a single patient before, during, and after pregnancy, over a period of 7\u00a0years. GI symptoms significantly improved, and plasma deoxyribonucleotide concentrations decreased during pregnancy. Within days after delivery, the patient\u2019s digestive symptoms recurred, coinciding with a rapid increase in plasma deoxyribonucleotide concentrations. We hypothesize that the clinico\u2010metabolic improvements could be attributed to the enzyme replacement action of the placental thymidine phosphorylase.<\/jats:p>","DOI":"10.1002\/acn3.51202","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T13:00:41Z","timestamp":1604754041000},"page":"2484-2488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pregnancy in MNGIE: a clinical and metabolic honeymoon"],"prefix":"10.1002","volume":"7","author":[{"given":"Pauline","family":"Pappalardo","sequence":"first","affiliation":[{"name":"D\u00e9partement de Neurop\u00e9diatrie CHU Gui de Chauliac Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Benoist","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie m\u00e9tabolomique H\u00f4pital Necker APHP Paris 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