{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:47:51Z","timestamp":1790351271805,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha\u2010synuclein in the brain, which was indicated by alpha\u2010synuclein levels in cerebrospinal fluid (CSF). We aimed to investigate associations of sleep characteristics with CSF alpha\u2010synuclein in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study recruited 536 cognitively intact individuals (aged between 40 and 90\u00a0years old) from the Chinese Alzheimer\u2019s Biomarker and Lifestyle study. Sleep behaviors were assessed by Pittsburgh Sleep Quality Index and total alpha\u2010synuclein in CSF was measured by enzyme\u2010linked immune\u2010sorbent assay. We used multiple linear and non\u2010linear regression models for research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant non\u2010linear associations of CSF alpha\u2010synuclein with sleep time and duration were revealed. Individuals who went to bed and fell asleep too early or late tended to have lower CSF alpha\u2010synuclein (reflection point for time to bed and fall asleep were 10:26 p.m. and 10:40 p.m.). Lower CSF alpha\u2010synuclein was also observed in individuals with either excessive or insufficient sleep duration (reflection point: 7.24\u00a0hours). Besides, overall poor sleep quality (\u03b2\u00a0=\u00a0\u22120.0621; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0242), longer sleep latency (\u03b2\u00a0=\u00a0\u22120.0415; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0174) and lower sleep efficiency (\u03b2\u00a0=\u00a00.0036; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0017) showed linear associations with lower CSF alpha\u2010synuclein. Sleep disturbances and daytime dysfunction were not significantly associated with CSF alpha\u2010synuclein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Poor sleep was associated with lower levels of CSF alpha\u2010synuclein in older adults, which may provide new insight into the prevention of synucleinopathies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51204","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T09:42:46Z","timestamp":1600508566000},"page":"2026-2034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Associations of sleep characteristics with alpha\u2010synuclein in cerebrospinal fluid in older adults"],"prefix":"10.1002","volume":"7","author":[{"given":"Xiao\u2010Tong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Lin","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Qingdao Municipal Hospital Qingdao University China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Ning","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-0898","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-0547","authenticated-orcid":false,"given":"Jin\u2010Tai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1503\/cmaj.060792","article-title":"Sleep and aging: 1. 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