{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:52Z","timestamp":1787755492912,"version":"build-2784847793"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the levels of brain\u2010derived neurotrophic factor (BDNF) in the serum of patients suffering from multiple sclerosis (MS) to evaluate the potential of serum BDNF as a biomarker for MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a recently validated enzyme\u2010linked immunoassay (ELISA) we measured BDNF in patients with MS (pwMS), diagnosed according to the 2001 McDonald criteria and aged between 18 and 70\u00a0years, participating in a long\u2010term cohort study with annual clinical visits, including blood sampling, neuropsychological testing, and brain magnetic resonance imaging (MRI). The results were compared with an age\u2010 and sex\u2010matched cohort of healthy controls (HC). Correlations between BDNF levels and a range of clinical and magnetic resonance imaging variables were assessed using an adjusted linear model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 259 pwMS and 259 HC were included, with a mean age of 44.42\u00a0\u00b1\u00a011.06 and 44.31\u00a0\u00b1\u00a011.26\u00a0years respectively. Eleven had a clinically isolated syndrome (CIS), 178 relapsing remitting MS (RRMS), 56 secondary progressive MS (SPMS), and 14 primary progressive MS (PPMS). Compared with controls, mean BDNF levels were lower by 8 % (p\u02c20.001) in pwMS. The level of BDNF in patients with SPMS was lower than in RRMS (p\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>We conclude that while the use of comparatively large cohorts enables the detection of a significant difference in BDNF levels between pwMS and HC, the difference is small and unlikely to usefully inform decision\u2010making processes at an individual patient level.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51215","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T18:37:58Z","timestamp":1602182278000},"page":"2251-2261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Levels of brain\u2010derived neurotrophic factor in patients with multiple sclerosis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1315-4100","authenticated-orcid":false,"given":"Yvonne","family":"Naegelin","sequence":"first","affiliation":[{"name":"Neurologic Clinic and Policlinic Departments of Medicine Clinical Research, Biomedicine and Biomedical Engineering University Hospital and University of Basel Basel 4031 Switzerland"},{"name":"School of Biosciences Cardiff University Cardiff CF10 3AX United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Saeuberli","sequence":"additional","affiliation":[{"name":"School of Biosciences Cardiff University Cardiff CF10 3AX United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schaedelin","sequence":"additional","affiliation":[{"name":"Clinical Trial Unit Department of Clinical Research University Hospital Basel Basel 4031 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Dingsdale","sequence":"additional","affiliation":[{"name":"School of Biosciences Cardiff University Cardiff CF10 3AX United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Magon","sequence":"additional","affiliation":[{"name":"Neurologic Clinic and Policlinic Departments of Medicine Clinical Research, Biomedicine and Biomedical Engineering University Hospital and University of Basel Basel 4031 Switzerland"},{"name":"Pharma Research and Early Development Roche Innovation Center Basel F. 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