{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:26:29Z","timestamp":1789500389584,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ek0109376"],"award-info":[{"award-number":["JP20ek0109376"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the frequency and patterns of optic, trigeminal, and facial nerve involvement by neuroimaging and electrophysiology in IgG4 anti\u2010neurofascin 155 antibody\u2010positive (NF155<jats:sup>+<\/jats:sup>) chronic inflammatory demyelinating polyneuropathy (CIDP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen IgG4 NF155<jats:sup>+<\/jats:sup> CIDP patients with mean onset age of 34\u00a0years (11 men) were subjected to neurological examination, blink reflex, and visual\u2010evoked potential (VEP) testing, and axial and\/or coronal T2\u2010weighted head magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 13 patients, facial sensory impairment, facial weakness, and apparent visual impairment were observed in three (23.1%), two (15.4%), and two (15.4%) patients, respectively. All 12 patients tested had blink reflex abnormalities: absent and\/or delayed R1 in 11 (91.7%), and absent and\/or delayed R2 in 10 (83.3%). R1 latencies had strong positive correlations with serum anti\u2010NF155 antibody levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.9, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.0001 on both sides) and distal and F wave latencies of the median and ulnar nerves. Absent and\/or prolonged VEPs were observed in 10\/13 (76.9%) patients and 17\/26 (65.4%) eyes. On MRI, hypertrophy, and high signal intensity of trigeminal nerves were detected in 9\/13 (69.2%) and 10\/13 (76.9%) patients, respectively, whereas optic nerves were normal in all patients. The intra\u2010orbital trigeminal nerve width on coronal sections showed a significant positive correlation with disease duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Subclinical demyelination frequently occurs in the optic, trigeminal, and facial nerves in IgG4 NF155<jats:sup>+<\/jats:sup> CIDP, suggesting that both central and peripheral myelin structures of the cranial nerves are involved in this condition, whereas nerve hypertrophy only develops in myelinated peripheral nerve fibers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51220","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T18:23:36Z","timestamp":1603218216000},"page":"2297-2309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Optic, trigeminal, and facial neuropathy related to anti\u2010neurofascin 155 antibody"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-9731","authenticated-orcid":false,"given":"Hidenori","family":"Ogata","sequence":"first","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Translational Neuroscience Center Graduate School of Medicine International University of Health and Welfare Okawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeko","family":"Inamizu","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichiro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-7861","authenticated-orcid":false,"given":"Ryo","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4629-1312","authenticated-orcid":false,"given":"Takuya","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Isobe","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Hiwatashi","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Tobimatsu","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Center Graduate School of Medicine International University of Health and Welfare Okawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010ichi","family":"Kira","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Translational Neuroscience Center Graduate School of Medicine International University of Health and Welfare Okawa Japan"},{"name":"School of Pharmacy at Fukuoka International University of Health and Welfare Okawa Japan"},{"name":"Department of Neurology, Brain and Nerve Center Fukuoka Central Hospital International University of Health and Welfare Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.121"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00245.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200103)24:3<311::AID-MUS1001>3.0.CO;2-A"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1459"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1212\/01.WNL.0000137033.77605.B2","article-title":"Hypertrophic cranial nerve roots in CIDP","volume":"63","author":"Inoue H","year":"2004","journal-title":"Neurology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e318064c59b"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2011-000040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000553"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64032-1.00015-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199812)21:12<1673::AID-MUS8>3.0.CO;2-A"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20679"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25731"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx124"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.248"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23794"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww189"},{"key":"e_1_2_8_18_1","first-page":"29","article-title":"A nationwide survey of combined central and peripheral demyelination in Japan","volume":"87","author":"Ogata H","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aa9c"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002418"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000238"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03312.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00997"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(93)90023-I"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004773"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-020-10041-z","article-title":"Antibodies against the node of Ranvier: a real\u2010life evaluation of incidence, clinical features and response to treatment based on a prospective analysis of 1500 sera","author":"Delmont E","year":"2020","journal-title":"J Neurol"},{"key":"e_1_2_8_27_1","article-title":"Distinguish CIDP with autoantibody from that without autoantibody: pathogenesis, histopathology, and clinical features","author":"Tang L","year":"2020","journal-title":"J. Neurol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2019.577074"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.11.035"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00478-8"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520330104017"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12226"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.260"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003616"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/01658107.2013.809459"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314895"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25757"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50931"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.51220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T05:08:27Z","timestamp":1693717707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,20]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/acn3.51220"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51220","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,20]]},"assertion":[{"value":"2020-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}