{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:53:48Z","timestamp":1783947228377,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether multiple sessions of transcranial direct current stimulation (tDCS) applied to the primary motor (M1) cortex paired with aerobic exercise can improve walking functions in multiple sclerosis (MS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MS participants were recruited for a double\u2010blind, parallel\u2010arm, randomized, sham\u2010controlled trial and assigned to 10 sessions (5 d\/wk for 2\u00a0weeks) of either active or sham tDCS paired with unloaded cycling for 20\u00a0minutes. Stimulation was administered over the left M1 cortex (2.5\u00a0mA; anode over C3\/cathode over FP2). Gait spatiotemporal parameters were assessed using a wearable inertial sensor (10\u2010meter and 2\u2010minute walking tests). Measurements were collected at baseline, end of tDCS intervention, and 4\u2010week postintervention to test for duration of any benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 participants completed the study, nine in the active and six in the sham condition. The active and sham groups were matched according to gender (50% vs. 40% female), neurologic disability (median EDSS 5.5 vs. 5), and age (mean 52.1\u00a0\u00b1\u00a012.9 vs. 53.7\u00a0\u00b1\u00a09.8\u00a0years). The active group had a significantly greater increase in gait speed (0.87 vs. 1.20\u00a0m\/s, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and distance covered during the 2\u2010minute walking test (118.53 vs. 133.06\u00a0m, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) at intervention end compared to baseline. At 4\u2010week follow\u2010up, these improvements were maintained (baseline vs. follow\u2010up: gait speed 0.87 vs. 1.18\u00a0m\/s, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; distance traveled 118.53 vs. 143.82\u00a0m, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Multiple sessions of tDCS paired with aerobic exercise lead to cumulative and persisting improvements in walking and endurance in patients with MS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51224","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T18:24:21Z","timestamp":1603218261000},"page":"2310-2319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Walking in multiple sclerosis improves with tDCS: a randomized, double\u2010blind, sham\u2010controlled 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