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The value of this approach has never been more evident than during the current COVID\u201019 pandemic. We sought to (1) establish and implement the infrastructure for longitudinal, virtual follow\u2010up of clinical trial participants, (2) compare changes in smartphone\u2010based assessments, online patient\u2010reported outcomes, and remote expert assessments, and (3) explore novel digital markers of Parkinson\u2019s disease disability and progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants from two recently completed phase III clinical trials of inosine and isradipine enrolled in Assessing Tele\u2010Health Outcomes in Multiyear Extensions of Parkinson\u2019s Disease trials (AT\u2010HOME PD), a two\u2010year virtual cohort study. After providing electronic informed consent, individuals complete annual video visits with a movement disorder specialist, smartphone\u2010based assessments of motor function and socialization, and patient\u2010reported outcomes online.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the two clinical trials, 226 individuals from 42 states in the United States and Canada enrolled. Of these, 181 (80%) have successfully downloaded the study\u2019s smartphone application and 161 (71%) have completed patient\u2010reported outcomes on the online platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>It is feasible to conduct a large\u2010scale, international virtual observational study following the completion of participation in brick\u2010and\u2010mortar clinical trials in Parkinson\u2019s disease. This study, which brings research to participants, will compare established clinical endpoints with novel digital biomarkers and thereby inform the longitudinal follow\u2010up of clinical trial participants and design of future clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51236","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:36:13Z","timestamp":1608683773000},"page":"308-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Design of a virtual longitudinal observational study in Parkinson\u2019s disease (AT\u2010HOME PD)"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-4041","authenticated-orcid":false,"given":"Ruth B.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Neurology University of Rochester Medical Center Rochester New York USA"},{"name":"Center for Health + Technology University of Rochester Medical Center Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larsson","family":"Omberg","sequence":"additional","affiliation":[{"name":"Sage Bionetworks Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Macklin","sequence":"additional","affiliation":[{"name":"Biostatistics Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Daeschler","sequence":"additional","affiliation":[{"name":"The Michael J. 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