{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:40:59Z","timestamp":1791592859233,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:00:00Z","timestamp":1608854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accelerated long\u2010term forgetting (ALF) refers to a rapid loss of information over days or weeks despite normal acquisition\/encoding. Notwithstanding its potential relevance as a presymptomatic marker of cognitive dysfunction, no study has addressed the relationship between ALF and Alzheimer\u2019s disease (AD) biomarkers. We examined ALF in APOE \u025b4 carriers versus noncarriers, and its relationships with AD cerebrospinal fluid (CSF) biomarkers. We found ALF over three months in APOE \u025b4 carriers (<jats:italic>F<\/jats:italic>(1,19)\u00a0=\u00a05.60; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05; Cohen\u2019s <jats:italic>d<\/jats:italic>\u00a0=\u00a01.08), and this performance was associated with abnormal levels of the CSF A\u03b2<jats:sub>42<\/jats:sub>\/ptau ratio (r\u00a0=\u00a0\u2212.614; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01). Our findings indicate that ALF is detectable in at\u2010risk individuals, and that there is a relationship between ALF and the pathophysiological processes underlying AD.<\/jats:p>","DOI":"10.1002\/acn3.51245","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T13:11:19Z","timestamp":1608901879000},"page":"477-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Accelerated long\u2010term forgetting over three months in asymptomatic APOE \u025b4 carriers"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-0482","authenticated-orcid":false,"given":"Adri\u00e0","family":"Tort\u2010Merino","sequence":"first","affiliation":[{"name":"Alzheimer\u2019s Disease and other Cognitive Disorders Unit Neurology Service, Hospital Cl\u00ednic of Barcelona Barcelona Spain"},{"name":"Institute of Neurosciences University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Laine","sequence":"additional","affiliation":[{"name":"Department of Psychology \u00c5bo Akademi University Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Valech","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and other Cognitive Disorders Unit Neurology Service, Hospital Cl\u00ednic of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Olives","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and other Cognitive Disorders Unit Neurology Service, Hospital Cl\u00ednic of Barcelona Barcelona Spain"},{"name":"Institute of Neurosciences University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and other Cognitive Disorders Unit Neurology Service, Hospital Cl\u00ednic of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Ecay\u2010Torres","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Terapias Avanzadas, Neurolog\u00eda CITA\u2010Alzheimer Foundation San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainara","family":"Estanga","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Terapias Avanzadas, Neurolog\u00eda CITA\u2010Alzheimer Foundation San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mart\u00ednez\u2010Lage","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Terapias Avanzadas, Neurolog\u00eda CITA\u2010Alzheimer Foundation San Sebasti\u00e1n 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