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In this pilot study, we analyzed the secondary structure distribution of TDP\u201043 in cerebrospinal fluid of ALS patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a036) compared to Parkinson\u00b4s disease patients (PD; <jats:italic>n<\/jats:italic>\u00a0=\u00a030) and further controls (Ctrl; <jats:italic>n<\/jats:italic>\u00a0=\u00a024) using the immuno\u2010infrared sensor technology. ALS patients could be discriminated from PD and Ctrl with a sensitivity\/specificity of 89 %\/77 % and 89 %\/83 %, respectively. Our findings demonstrate that TDP\u201043 misfolding measured by the immuno\u2010infrared sensor technology has the potential to serve as a biomarker candidate for ALS.<\/jats:p>","DOI":"10.1002\/acn3.51256","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T22:06:23Z","timestamp":1606946783000},"page":"271-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["TDP\u201043 as structure\u2010based biomarker in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-6044","authenticated-orcid":false,"given":"L\u00e9on","family":"Beyer","sequence":"first","affiliation":[{"name":"Center for Protein Diagnostics (ProDi) Ruhr University Bochum Bochum Germany"},{"name":"Faculty of Biology and Biotechnology Department of Biophysics Ruhr University Bochum Bochum 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