{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:49:46Z","timestamp":1784224186151,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little information is available in spinocerebellar ataxias (SCAs) regarding pelvic organ symptoms. The aim of this study was to characterize the lower urinary tract (LUT) and bowel dysfunction in autosomal dominant spinocerebellar ataxias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with confirmed SCAs attending a tertiary care service were approached about LUT and bowel complaints, and completed validated questionnaires: urinary symptom profile (USP), Qualiveen\u2010Short form, International Prostate Symptom Score, and Neurogenic Bowel Dysfunction Score. SCA3 and SCA7 patients with urological complaints additionally underwent urodynamic studies (UDS). Patients\u2019 characterization included demographic, clinical (Scale for the Assessment and Rating of Ataxia (SARA), Inventory of Non\u2010Ataxia Signs (INAS)), and genetic variables. Descriptive and comparative analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one patients participated: SCA1 (n\u00a0=\u00a04), SCA2 (n\u00a0=\u00a011), SCA3 (n\u00a0=\u00a013), SCA6 (n\u00a0=\u00a017), and SCA7 (n\u00a0=\u00a06). The prevalence of self\u2010reported LUT symptoms was 60.8% (n\u00a0=\u00a031), whereas LUT symptoms was reported in 86.3%(n\u00a0=\u00a044) using the USP. Both storage and voiding symptoms were reported, urinary frequency and urgency being the most frequent (n\u00a0=\u00a034, 68%). Although LUT symptoms were most often classed as mild (n\u00a0=\u00a027, 61.4%), they impacted QoL in 38 patients (77.6%). Of these, 21 (55.3%) were not on pharmacological treatment for urinary dysfunction. Most common abnormalities in UDS (n\u00a0=\u00a014) were detrusor overactivity (storage phase) and detrusor underactivity (voiding phase). Bowel symptoms were less common (31.4%, n\u00a0=\u00a016) and of mild severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LUT symptoms are prevalent in SCA patients and impact QoL, whereas bowel symptoms tend to be mild. These symptoms are overlooked by patients and physicians due to the complexity of neurological involvement in SCA, and therefore a multidisciplinary management approach should be adopted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51266","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T22:09:32Z","timestamp":1608329372000},"page":"321-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lower urinary tract and bowel dysfunction in spinocerebellar ataxias"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-3106","authenticated-orcid":false,"given":"Joana","family":"Afonso Ribeiro","sequence":"first","affiliation":[{"name":"Ataxia Service Department of Clinical and Movement Neurosciences and Department of Neurogenetics The National Hospital for Neurology and Neurosurgery and UCL Queen Square Institute of Neurology Faculty of Brain Sciences 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