{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:22:40Z","timestamp":1784172160718,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:00:00Z","timestamp":1608854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pivotal trial have shown that patients with multiple sclerosis (MS) receiving ocrelizumab had better outcomes. However, data on ocrelizumab in clinical practice are limited. The aim of this study was to evaluate the preliminary safety profile and effectiveness of ocrelizumab treatment for multiple sclerosis (MS) in a real\u2010world clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study including consecutive patients from nine public hospitals in south\u2010eastern Spain who received ocrelizumab after it was approved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 228 MS patients were included (144 with relapsing\u2013remitting MS [RRMS], 25 secondary progressive MS [SPMS], and 59 primary progressive MS [PPMS]). Median follow\u2010up period was 12\u00a0months (range, 1\u201032). No evidence of disease activity (NEDA) status at year 1 was achieved in 91.2% of the relapsing MS (RMS) population, while disability progression was detected in 37.5% of the PPMS patients (median follow\u2010up period, 19\u00a0months). The most common adverse events reported were infusion\u2010related reactions and infections, with the most common infections being urinary tract infections followed by upper respiratory infections and COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The preliminary results in our real\u2010world setting show that ocrelizumab presented excellent results in suppressing disease activity with a favorable and consistent safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51282","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T13:24:40Z","timestamp":1608902680000},"page":"385-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Real\u2010world experience of ocrelizumab in multiple sclerosis in a Spanish population"],"prefix":"10.1002","volume":"8","author":[{"given":"Eva","family":"Fernandez\u2010Diaz","sequence":"first","affiliation":[{"name":"Neurology Department Complejo Hospitalario Universitario de Albacete Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Perez\u2010Vicente","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Universitario Santa Luc\u00eda Cartagena Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Villaverde\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Morales y Meseguer Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Berenguer\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Marina Baixa La Vila\u2010Joiosa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Candeliere Merlicco","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Rafael M\u00e9ndez Lorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Martinez\u2010Navarro","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Reina Sofia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gracia Gil","sequence":"additional","affiliation":[{"name":"Neurology Department Complejo Hospitalario Universitario de Albacete Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Romero\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Neurology Department Complejo Hospitalario Universitario de Albacete Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Alfaro\u2010Saez","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Vega Baja Orihuela Spain"},{"name":"Center for Biomedical Research in the Network in Bioengineering Biomaterials and Nanomedicine (CIBER\u2010BBN) Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Diaz","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Universitario Santa Luc\u00eda Cartagena Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Gimenez\u2010Martinez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Alicante Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angeles","family":"Mendez\u2010Miralles","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Universitario Los Arcos del Mar Menor Murcia Spain"},{"name":"Universidad Cat\u00f3lica de Murcia (UCAM) Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Millan\u2010Pascual","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Universitario Santa Luc\u00eda Cartagena Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Jimenez\u2010Pancho","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Vega Baja Orihuela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Mola","sequence":"additional","affiliation":[{"name":"Section of Neurology Hospital Vega Baja Orihuela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0195-2834","authenticated-orcid":false,"given":"Angel P.","family":"Sempere","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Alicante Alicante Spain"},{"name":"Department of Clinical Medicine Miguel Hern\u00e1ndez University San Juan de Alicante Spain"},{"name":"ISABIAL Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,25]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Ocrevus: EPAR\u2010Product information. 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