{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:03:50Z","timestamp":1785236630454,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To define the clinicopathologic features and diagnostic utility associated with anti\u2010cytosolic 5\u2032\u2010nucleotidase 1A (NT5C1A) antibody seropositivity in idiopathic inflammatory myopathies (IIMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Anti\u2010NT5C1A antibody status was clinically tested between 2014 and 2019 in the Washington University neuromuscular clinical laboratory. Using clinicopathologic information available for 593 patients, we classified them as inclusion body myositis (IBM), dermatomyositis, antisynthetase syndrome, immune\u2010mediated necrotizing myopathy (IMNM), nonspecific myositis, or noninflammatory muscle diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 593 patients, anti\u2010NT5C1A antibody was found in 159\/249 (64%) IBM, 11\/53 (21%) dermatomyositis, 7\/27 (26%) antisynthetase syndrome, 9\/76 (12%) IMNM, 20\/84 (24%) nonspecific myositis, and 6\/104 (6%) noninflammatory muscle diseases patients. Among patients with IBM, anti\u2010NT5C1A antibody seropositive patients had more cytochrome oxidase\u2010negative fibers compared with anti\u2010NT5C1A antibody seronegative patients. Among 14 IBM patients initially negative for anti\u2010NT5C1A antibody, three patients (21%) converted to positive. Anti\u2010NT5C1A antibody seropositivity did not correlate with malignancy, interstitial lung disease, response to treatments in dermatomyositis, antisynthetase syndrome, and IMNM, or survival in IIMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Anti\u2010NT5C1A antibody is associated with IBM. However, the seropositivity can also be seen in non\u2010IBM IIMs and it does not correlate with any prognostic factors or survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51294","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T01:45:25Z","timestamp":1612835125000},"page":"571-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Clinical utility of anti\u2010cytosolic 5\u2019\u2010nucleotidase 1A antibody in idiopathic inflammatory myopathies"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-1696","authenticated-orcid":false,"given":"Chiseko","family":"Ikenaga","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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